Immunology Antibodies 1

Anti-TLR8 Antibody (CAB12906)

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SKU:
CAB12906
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-TLR8 Antibody
Antibody SKU:CAB12906
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 849-1041 of human TLR8 (NP_619542.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, NCI-H460, LO2, Mouse spleen , Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 849-1041 of human TLR8 (NP_619542.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HHLF YWDV WFIY NVCL AKVK GYRS LSTS QTFY DAYI SYDT KDAS VTDW VINE LRYH LEES RDKN VLLC LEER DWDP GLAI IDNL MQSI NQSK KTVF VLTK KYAK SWNF KTAF YLAL QRLM DENM DVII FILL EPVL QHSQ YLRL RQRI CKSS ILQW PDNP KAEG LFWQ TLRN VVLT ENDS RYNN MYVD SIKQ Y
Gene ID:51311
Uniprot:Q9NR97
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:119kDa/121kDa
Observed MW:120kDa
Synonyms:TLR8, CD288, TLR8
Background:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
UniProt Protein Function:TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane

Molecular Function:single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; receptor activity; drug binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; response to virus; positive regulation of interleukin-8 biosynthetic process; microglial cell activation; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-beta biosynthetic process; positive regulation of innate immune response; toll-like receptor signaling pathway; innate immune response; immunoglobulin mediated immune response; toll-like receptor 9 signaling pathway; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process

NCBI Summary:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NR97
NCBI GenInfo Identifier:20140873
NCBI Gene ID:51311
NCBI Accession:Q9NR97.1
UniProt Secondary Accession:Q9NR97,Q495P4, Q6UXL6, Q9NYG9, B3Y654, D1CS70, D1CS76
UniProt Related Accession:Q9NR97
Molecular Weight:Calculated MW:1195Da/121kDaOberverd MW: 115kDa
NCBI Full Name:Toll-like receptor 8
NCBI Synonym Full Names:toll-like receptor 8
NCBI Official Symbol:TLR8  
NCBI Official Synonym Symbols:CD288  
NCBI Protein Information:toll-like receptor 8
UniProt Protein Name:Toll-like receptor 8
UniProt Synonym Protein Names:CD_antigen: CD288
Protein Family:Toll-like receptor
UniProt Gene Name:TLR8  
UniProt Entry Name:TLR8_HUMAN
Anti-TLR8 Antibody (CAB12906)Western blot analysis of extracts of various cell lines, using TLR8 antibody (CAB12906) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-TLR8 Antibody (CAB12906)Immunofluorescence analysis of MCF-7 cells using TLR8 antibody (CAB12906). Blue: DAPI for nuclear staining.
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