Epigenetics & Nuclear Signaling Antibodies 3
Anti-TLE1 Antibody (CAB5501)
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- SKU:
- CAB5501
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TLE1 Antibody |
| Antibody SKU: | CAB5501 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 501-770 of human TLE1 (NP_005068.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 501-770 of human TLE1 (NP_005068.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TGGK GCVK VWDI SHPG NKSP VSQL DCLN RDNY IRSC KLLP DGCT LIVG GEAS TLSI WDLA APTP RIKA ELTS SAPA CYAL AISP DSKV CFSC CSDG NIAV WDLH NQTL VRQF QGHT DGAS CIDI SNDG TKLW TGGL DNTV RSWD LREG RQLQ QHDF TSQI FSLG YCPT GEWL AVGM ESSN VEVL HVNK PDKY QLHL HESC VLSL KFAY CGKW FVST GKDN LLNA WRTP YGAS IFQS KESS SVLS CDIS VDDK YIVT GSGD KKAT VYEV IY |
| Gene ID: | 7088 |
| Uniprot: | Q04724 |
| Cellular Location: | Nucleus |
| Calculated MW: | 83kDa |
| Observed MW: | 83kDa |
| Synonyms: | TLE1, ESG, ESG1, GRG1 |
| Background: |
| UniProt Protein Function: | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
| UniProt Code: | Q04724 |
| NCBI GenInfo Identifier: | 29840816 |
| NCBI Gene ID: | 7088 |
| NCBI Accession: | Q04724.2 |
| UniProt Secondary Accession: | Q04724,Q5T3G4, Q969V9, A8K495, |
| UniProt Related Accession: | Q04724 |
| Molecular Weight: | 83,201 Da |
| NCBI Full Name: | Transducin-like enhancer protein 1 |
| NCBI Synonym Full Names: | transducin like enhancer of split 1 |
| NCBI Official Symbol: | TLE1 |
| NCBI Official Synonym Symbols: | ESG; ESG1; GRG1 |
| NCBI Protein Information: | transducin-like enhancer protein 1 |
| UniProt Protein Name: | Transducin-like enhancer protein 1 |
| UniProt Synonym Protein Names: | E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1 |
| Protein Family: | Transducin-like enhancer protein |
| UniProt Gene Name: | TLE1 |
| UniProt Entry Name: | TLE1_HUMAN |
 | Western blot analysis of extracts of THP-1 cells, using TLE1 antibody (CAB5501) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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