Signal Transduction Antibodies 2
Anti-TIMP3 Antibody (CAB1511)
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- SKU:
- CAB1511
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-TIMP3 Antibody |
| Antibody SKU: | CAB1511 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-211 of human TIMP3 (NP_000353.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-211 of human TIMP3 (NP_000353.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CTCS PSHP QDAF CNSD IVIR AKVV GKKL VKEG PFGT LVYT IKQM KMYR GFTK MPHV QYIH TEAS ESLC GLKL EVNK YQYL LTGR VYDG KMYT GLCN FVER WDQL TLSQ RKGL NYRY HLGC NCKI KSCY YLPC FVTS KNEC LWTD MLSN FGYP GYQS KHYA CIRQ KGGY CSWY RGWA PPDK SIIN ATDP |
| Gene ID: | 7078 |
| Uniprot: | P35625 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 24kDa |
| Observed MW: | Refer to figures |
| Synonyms: | TIMP3, HSMRK222, K222, K222TA2, SFD |
| Background: | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. |
| UniProt Protein Function: | TIMP3: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 22q12.3 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; basement membrane; nucleus Molecular Function:metalloendopeptidase inhibitor activity; protein binding; protease binding; metal ion binding Biological Process: negative regulation of metalloenzyme activity; visual perception; response to cytokine stimulus; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis Disease: Fundus Dystrophy, Pseudoinflammatory, Of Sorsby |
| NCBI Summary: | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35625 |
| NCBI GenInfo Identifier: | 730948 |
| NCBI Gene ID: | 7078 |
| NCBI Accession: | P35625.2 |
| UniProt Secondary Accession: | P35625,Q5THV4, Q9UC74, Q9UGS2, B2RBY9, |
| UniProt Related Accession: | P35625 |
| Molecular Weight: | 24,145 Da |
| NCBI Full Name: | Metalloproteinase inhibitor 3 |
| NCBI Synonym Full Names: | TIMP metallopeptidase inhibitor 3 |
| NCBI Official Symbol: | TIMP3 |
| NCBI Official Synonym Symbols: | SFD; K222; K222TA2; HSMRK222 |
| NCBI Protein Information: | metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3 |
| UniProt Protein Name: | Metalloproteinase inhibitor 3 |
| UniProt Synonym Protein Names: | Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3 |
| Protein Family: | Metalloproteinase inhibitor |
| UniProt Gene Name: | TIMP3 |
| UniProt Entry Name: | TIMP3_HUMAN |
 | Immunofluorescence analysis of MCF-7 cells using TIMP3 antibody (CAB1511). Blue: DAPI for nuclear staining. |
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