Anti-TIMP2 Antibody (CAB20766)
- SKU:
- CAB20766
Description
| Antibody Name: | Anti-TIMP2 Antibody (CAB20766) |
| Antibody SKU: | CAB20766 |
| Antibody Size: | 50µL, 100µL |
| Application: | Western blotting |
| Reactivity: | Human, Mouse, Rat, African green monkey |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TIMP2. |
| Application: | Western blotting |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat, African green monkey |
| Positive Samples: | SH-SY5Y, HT-1080, Rat brain, COS-7, Mouse testis, Mouse brain, Mouse lung |
| Immunogen: | Recombinant protein of human TIMP2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VSLD VGGK KEYL IAGK AEGD GKMH ITLC DFIV PWDT LSTT QKKS LNHR YQMG CECK ITRC PMIP CYIS SPDE CLWM DWVT EKNI NGHQ AKFF ACIK RSDG S |
| Cellular Location: | Secreted |
| Calculated MW: | 24kDa |
| Observed MW: | 22kDa |
| Synonyms: | TIMP2, CSC-21K, DDC8 |
| Background: | This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. |
 | Western blot analysis of extracts of various cell lines, using TIMP2 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s. |
 | Western blot analysis of extracts of various cell lines, using TIMP2 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 20s. |
Additional Information
Product Type: |
Antibody |
Antibody Type: |
Secondary Antibody |
Host Species: |
Goat |
Isotype: |
Fluorescein conjugated IgG |
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