Cell Biology Antibodies 16
Anti-TIMM50 Antibody (CAB9991)
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- SKU:
- CAB9991
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TIMM50 Antibody |
| Antibody SKU: | CAB9991 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-456 of human TIMM50 (NP_001001563.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:4000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | B cells, Mouse heart, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-456 of human TIMM50 (NP_001001563.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GNNP VDEN GAKI PDEF DNDP ILVQ QLRR TYKY FKDY RQMI IEPT SPCL LPDP LQEP YYQP PYTL VLEL TGVL LHPE WSLA TGWR FKKR PGIE TLFQ QLAP LYEI VIFT SETG MTAF PLID SVDP HGFI SYRL FRDA TRYM DGHH VKDI SCLN RDPA RVVV VDCK KEAF RLQP YNGV ALRP WDGN SDDR VLLD LSAF LKTI ALNG VEDV RTVL EHYA LEDD PLAA FKQR QSRL EQEE QQRL AELS KSNK QNLF LGSL TSRL WPRS KQP |
| Gene ID: | 92609 |
| Uniprot: | Q3ZCQ8 |
| Cellular Location: | Mitochondrion inner membrane, Nucleus speckle, Single-pass membrane protein |
| Calculated MW: | 27kDa/39kDa/50kDa |
| Observed MW: | 39kDa |
| Synonyms: | TIMM50, TIM50, TIM50L |
| Background: |
| UniProt Protein Function: | TIMM50: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. Belongs to the TIM50 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: mitochondrial inner membrane; mitochondrial inner membrane presequence translocase complex; mitochondrion; nuclear speck; nucleoplasm Molecular Function:interleukin-2 receptor binding; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; ribonucleoprotein binding Biological Process: mitochondrial membrane organization and biogenesis; protein amino acid dephosphorylation; protein import into mitochondrial matrix; release of cytochrome c from mitochondria |
| NCBI Summary: | This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q3ZCQ8 |
| NCBI GenInfo Identifier: | 83305924 |
| NCBI Gene ID: | 92609 |
| NCBI Accession: | Q3ZCQ8.2 |
| UniProt Secondary Accession: | Q3ZCQ8,Q330K1, Q6QA00, Q96FJ5, Q96GY2, Q9H370, |
| UniProt Related Accession: | Q3ZCQ8 |
| Molecular Weight: | 27,579 Da |
| NCBI Full Name: | Mitochondrial import inner membrane translocase subunit TIM50 |
| NCBI Synonym Full Names: | translocase of inner mitochondrial membrane 50 |
| NCBI Official Symbol: | TIMM50 |
| NCBI Official Synonym Symbols: | TIM50; TIM50L |
| NCBI Protein Information: | mitochondrial import inner membrane translocase subunit TIM50 |
| UniProt Protein Name: | Mitochondrial import inner membrane translocase subunit TIM50 |
| Protein Family: | Mitochondrial import inner membrane translocase |
| UniProt Gene Name: | TIMM50 |
| UniProt Entry Name: | TIM50_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TIMM50 antibody (CAB9991) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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