Anti-TIMM50 Antibody (CAB1536)
- SKU:
- CAB1536
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- TIM50
- Synonyms:
- TIM50L
- Research Area:
- Cell Biology
Description
| Product Name: | TIMM50 Rabbit mAb |
| Product Code: | CAB1536 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | TIM50, TIM50L |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human TIMM50 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HepG2, Mouse liver, Mouse brain |
| Immunogen: | A synthesized peptide derived from human TIMM50 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 92609 |
| Uniprot: | Q3ZCQ8 |
| Cellular Location: | Mitochondrion inner membrane, Nucleus speckle, Single-pass membrane protein |
| Calculated MW: | 36kDa |
| Observed MW: | 38kDa |
| UniProt Protein Function: | TIMM50: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. Belongs to the TIM50 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: mitochondrial inner membrane; mitochondrial inner membrane presequence translocase complex; mitochondrion; nuclear speck; nucleoplasm Molecular Function:interleukin-2 receptor binding; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; ribonucleoprotein binding Biological Process: mitochondrial membrane organization and biogenesis; protein amino acid dephosphorylation; protein import into mitochondrial matrix; release of cytochrome c from mitochondria |
| NCBI Summary: | This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q3ZCQ8 |
| NCBI GenInfo Identifier: | 83305924 |
| NCBI Gene ID: | 92609 |
| NCBI Accession: | Q3ZCQ8.2 |
| UniProt Secondary Accession: | Q3ZCQ8,Q330K1, Q6QA00, Q96FJ5, Q96GY2, Q9H370, |
| UniProt Related Accession: | Q3ZCQ8 |
| Molecular Weight: | 27,579 Da |
| NCBI Full Name: | Mitochondrial import inner membrane translocase subunit TIM50 |
| NCBI Synonym Full Names: | translocase of inner mitochondrial membrane 50 |
| NCBI Official Symbol: | TIMM50 |
| NCBI Official Synonym Symbols: | TIM50; TIM50L |
| NCBI Protein Information: | mitochondrial import inner membrane translocase subunit TIM50 |
| UniProt Protein Name: | Mitochondrial import inner membrane translocase subunit TIM50 |
| Protein Family: | Mitochondrial import inner membrane translocase |
| UniProt Gene Name: | TIMM50 |
| UniProt Entry Name: | TIM50_HUMAN |
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