Cell Biology Antibodies 9
Anti-TFRC Antibody (CAB5865)
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- SKU:
- CAB5865
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TFRC Antibody |
| Antibody SKU: | CAB5865 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TFRC (NP_001121620.1). |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Raji, HepG2, Jurkat, Mouse spleen, Mouse liver, Rat spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TFRC (NP_001121620.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMDQ ARSA FSNL FGGE PLSY TRFS LARQ VDGD NSHV EMKL AVDE EENA DNNT KANV TKPK RCSG SICY GTIA VIVF FLIG FMIG YLGY CKGV EPKT ECER LAGT ESPV REEP GEDF PAAR RLYW DDLK RKLS EKLD STDF |
| Gene ID: | 7037 |
| Uniprot: | P02786 |
| Cellular Location: | Cell membrane, Melanosome, Secreted, Single-pass type II membrane protein |
| Calculated MW: | 84kDa |
| Observed MW: | 100kDa |
| Synonyms: | TFRC, CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90 |
| Background: | This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. |
| UniProt Protein Function: | TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q29 Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome Molecular Function:double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity Biological Process: regulation of cell growth; regulation of cell proliferation; transferrin transport |
| NCBI Summary: | This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] |
| UniProt Code: | P02786 |
| NCBI GenInfo Identifier: | 108935939 |
| NCBI Gene ID: | 7037 |
| NCBI Accession: | P02786.2 |
| UniProt Secondary Accession: | P02786,Q1HE24, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21 D3DXB0, |
| UniProt Related Accession: | P02786 |
| Molecular Weight: | 84,871 Da |
| NCBI Full Name: | Transferrin receptor protein 1 |
| NCBI Synonym Full Names: | transferrin receptor |
| NCBI Official Symbol: | TFRC |
| NCBI Official Synonym Symbols: | T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46 |
| NCBI Protein Information: | transferrin receptor protein 1 |
| UniProt Protein Name: | Transferrin receptor protein 1 |
| UniProt Synonym Protein Names: | T9; p90; CD_antigen: CD71 |
| Protein Family: | Transferrin receptor protein |
| UniProt Gene Name: | TFRC |
| UniProt Entry Name: | TFR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TFRC antibody (CAB5865) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using TFRC antibody (CAB5865) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using TFRC antibody (CAB5865) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using TFRC antibody (CAB5865) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human placenta using TFRC antibody (CAB5865) at dilution of 1:100 (40x lens). |
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