Epigenetics & Nuclear Signaling Antibodies 4

Anti-TFAP2B Antibody (CAB7935)

(No reviews yet) Write a Review
SKU:
CAB7935
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TFAP2B Antibody
Antibody SKU:CAB7935
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human TFAP2B
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:SW620, Raji
Immunogen:A synthetic peptide of human TFAP2B
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7021
Uniprot:Q92481
Cellular Location:Nucleus
Calculated MW:50kDa/51kDa
Observed MW:50kDa
Synonyms:TFAP2B, AP-2B, AP2-B, PDA2
Background:This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
UniProt Protein Function:AP-2 beta: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Belongs to the AP-2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: nucleus

Molecular Function:caspase inhibitor activity; DNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity

Biological Process: calcium ion homeostasis; fat cell differentiation; forelimb morphogenesis; glucose homeostasis; glucose metabolic process; hindlimb morphogenesis; kidney development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphate ion homeostasis; positive regulation of cell proliferation; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; potassium ion homeostasis; regulation of BMP signaling pathway; regulation of cell differentiation; regulation of insulin secretion; regulation of transcription, DNA-dependent; renal water homeostasis; sodium ion homeostasis; sympathetic nervous system development

Disease: Char Syndrome

NCBI Summary:This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]
UniProt Code:Q92481
NCBI GenInfo Identifier:152031557
NCBI Gene ID:7021
NCBI Accession:Q92481.2
UniProt Secondary Accession:Q92481,Q5JYX6, Q9NQ63, Q9NU99, Q9UJI7, Q9Y214, Q9Y3K3
UniProt Related Accession:Q92481
Molecular Weight:51,524 Da
NCBI Full Name:Transcription factor AP-2-beta
NCBI Synonym Full Names:transcription factor AP-2 beta
NCBI Official Symbol:TFAP2B  
NCBI Official Synonym Symbols:PDA2; AP-2B; AP2-B  
NCBI Protein Information:transcription factor AP-2-beta
UniProt Protein Name:Transcription factor AP-2-beta
UniProt Synonym Protein Names:Activating enhancer-binding protein 2-beta
Protein Family:Transcription factor
UniProt Gene Name:TFAP2B  
UniProt Entry Name:AP2B_HUMAN
Anti-TFAP2B Antibody (CAB7935)Western blot analysis of extracts of various cell lines, using TFAP2B antibody (CAB7935) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
View AllClose

0 Reviews

View AllClose

Related Products