Signal Transduction Antibodies 1
Anti-TF Antibody (CAB1448)
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- SKU:
- CAB1448
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-TF Antibody |
| Antibody SKU: | CAB1448 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 399-698 of human TF (NP_001054.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A-549, MCF7, Mouse kidney, Mouse liver, Rat kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 399-698 of human TF (NP_001054.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KIMN GEAD AMSL DGGF VYIA GKCG LVPV LAEN YNKS DNCE DTPE AGYF AVAV VKKS ASDL TWDN LKGK KSCH TAVG RTAG WNIP MGLL YNKI NHCR FDEF FSEG CAPG SKKD SSLC KLCM GSGL NLCE PNNK EGYY GYTG AFRC LVEK GDVA FVKH QTVP QNTG GKNP DPWA KNLN EKDY ELLC LDGT RKPV EEYA NCHL ARAP NHAV VTRK DKEA CVHK ILRQ QQHL FGSN VTDC SGNF CLFR SETK DLLF RDDT VCLA KLHD RNTY EKYL GEEY VKAV GNLR KCST SSLL EACT FRRP |
| Gene ID: | 7018 |
| Uniprot: | P02787 |
| Cellular Location: | Secreted |
| Calculated MW: | 77kDa |
| Observed MW: | 77kDa |
| Synonyms: | HEL-S-71p, PRO1557, PRO2086, TFQTL1, TF, Transferrin |
| Background: | This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. |
| UniProt Protein Function: | TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3q22.1 Cellular Component: extracellular space; cell surface; early endosome; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; endocytic vesicle; apical plasma membrane; late endosome; basal plasma membrane; endosome membrane; vesicle Molecular Function:protein binding; ferric iron binding; ubiquitin protein ligase binding Biological Process: platelet activation; retinal homeostasis; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport Disease: Atransferrinemia |
| NCBI Summary: | This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P02787 |
| NCBI GenInfo Identifier: | 313104271 |
| NCBI Gene ID: | 7018 |
| NCBI Accession: | P02787.3 |
| UniProt Secondary Accession: | P02787,O43890, Q1HBA5, Q9NQB8, Q9UHV0, |
| UniProt Related Accession: | P02787 |
| Molecular Weight: | 77,064 Da |
| NCBI Full Name: | Serotransferrin |
| NCBI Synonym Full Names: | transferrin |
| NCBI Official Symbol: | TF |
| NCBI Official Synonym Symbols: | TFQTL1; PRO1557; PRO2086 |
| NCBI Protein Information: | serotransferrin; siderophilin; beta-1 metal-binding globulin |
| UniProt Protein Name: | Serotransferrin |
| UniProt Synonym Protein Names: | Beta-1 metal-binding globulin; Siderophilin |
| Protein Family: | Transferrin |
| UniProt Gene Name: | TF |
| UniProt Entry Name: | TRFE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TF antibody (CAB1448) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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