Developmental Biology
Anti-TESC Antibody (CAB8689)
- SKU:
- CAB8689
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-TESC Antibody |
| Antibody SKU: | CAB8689 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 135-214 of human TESC (NP_060369.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, U-87MG, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 135-214 of human TESC (NP_060369.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YRNV VEEL LSGN PHIE KESA RSIA DGAM MEAA SVCM GQME PDQV YEGI TFED FLKI WQGI DIET KMHV RFLN METM ALCH |
| Gene ID: | 54997 |
| Uniprot: | Q96BS2 |
| Cellular Location: | Cell membrane, Cell projection, Cytoplasm, Lipid-anchor, Membrane, Nucleus, lamellipodium, ruffle membrane |
| Calculated MW: | 18kDa/21kDa/24kDa |
| Observed MW: | 30kDa |
| Synonyms: | TESC, CHP3, TSC, tescalcin |
| Background: |
| UniProt Protein Function: | TESC: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. Belongs to the calcineurin regulatory subunit family. CHP subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 12q24.22 Cellular Component: cytoplasm; lamellipodium; nucleus; plasma membrane; ruffle Molecular Function:calcium ion binding; magnesium ion binding; phosphatase inhibitor activity; protein binding; protein homodimerization activity Biological Process: negative regulation of cell proliferation; positive regulation of granulocyte differentiation; positive regulation of megakaryocyte differentiation; positive regulation of sodium:hydrogen antiporter activity; positive regulation of transcription, DNA-dependent; protein maturation; protein stabilization; regulation of cell adhesion mediated by integrin |
| UniProt Code: | Q96BS2 |
| NCBI GenInfo Identifier: | 284018160 |
| NCBI Gene ID: | 54997 |
| NCBI Accession: | Q96BS2.3 |
| UniProt Secondary Accession: | Q96BS2,Q9NWT9, F5H1Y5, |
| UniProt Related Accession: | Q96BS2 |
| Molecular Weight: | 21,521 Da |
| NCBI Full Name: | Calcineurin B homologous protein 3 |
| NCBI Synonym Full Names: | tescalcin |
| NCBI Official Symbol: | TESC |
| NCBI Official Synonym Symbols: | TSC; CHP3 |
| NCBI Protein Information: | calcineurin B homologous protein 3 |
| UniProt Protein Name: | Calcineurin B homologous protein 3 |
| UniProt Synonym Protein Names: | Tescalcin; TSC |
| Protein Family: | Calcineurin B homologous protein |
| UniProt Gene Name: | TESC |
| UniProt Entry Name: | CHP3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TESC antibody (CAB8689) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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