Name: Anti-TEC Antibody (CAB0189)
Brand: Immunology Antibodies 1
SKU: CAB0189
Availability: OutOfStock

Antibody Name:	Anti-TEC Antibody
Antibody SKU:	CAB0189
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TEC (NP_003206.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, Mouse liver, Mouse thymus, Mouse spleen, Rat liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TEC (NP_003206.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MNFN TILE EILI KRSQ QKKK TSPL NYKE RLFV LTKS MLTY YEGR AEKK YRKG FIDV SKIK CVEI VKND DGVI PCQN KYPF QVVH DANT LYIF APSP QSRD LWVK KLKE EIKN NNNI MIKY HPKF WTDG SYQC CRQT EKLA PGCE KYNL FESS IRKA LPPA PETK KRRP PPPI PLEE EDNS EEIV VAMY DFQA AEGH DLRL ERGQ EYLI LEKN DVHW WRAR DKYG NEGY IPSN YVTG KKSN NLDQ YEWY CRNM NRSK AEQL LRSE DKEG GFMV RDSS QPGL
Gene ID:	7006
Uniprot:	P42680
Cellular Location:	Cell membrane, Cytoplasm, Peripheral membrane protein, cytoskeleton
Calculated MW:	73kDa
Observed MW:	68kDa

Synonyms:

TEC, PSCTK4

Background:

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.

UniProt Protein Function:	TEC: a non-receptor protein-tyrosine kinases of the Tec family. Containing a pleckstrin homology domain. Involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. May be an important signal transducer for cell division and/or for differentiation in the liver system.
UniProt Protein Details:	Protein type:Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; TK group; Tec family Chromosomal Location of Human Ortholog: 4p12 Cellular Component: cytoskeleton; cytosol; extrinsic to internal side of plasma membrane Molecular Function:non-membrane spanning protein tyrosine kinase activity; protein binding; receptor binding Biological Process: B cell receptor signaling pathway; cell differentiation; innate immune response; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; tissue regeneration; transmembrane receptor protein tyrosine kinase signaling pathway
NCBI Summary:	The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:	P42680
NCBI GenInfo Identifier:	158518392
NCBI Gene ID:	7006
NCBI Accession:	P42680.2
UniProt Secondary Accession:	P42680,Q3MIS5, B7ZKZ6,
UniProt Related Accession:	P42680
Molecular Weight:	73,581 Da
NCBI Full Name:	Tyrosine-protein kinase Tec
NCBI Synonym Full Names:	tec protein tyrosine kinase
NCBI Official Symbol:	TEC
NCBI Official Synonym Symbols:	PSCTK4
NCBI Protein Information:	tyrosine-protein kinase Tec
UniProt Protein Name:	Tyrosine-protein kinase Tec
Protein Family:	Tectonic
UniProt Gene Name:	TEC
UniProt Entry Name:	TEC_HUMAN

Western blot analysis of extracts of various cell lines, using TEC antibody (CAB0189) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

ELISA Kits

Human TEC / Tyrosine-protein kinase Tec ELISA Kit

Human Tyrosine-protein kinase Tec (TEC) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)