Developmental Biology

Anti-TDRD1 Antibody (CAB12882)

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SKU:
CAB12882
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-TDRD1 Antibody
Antibody SKU:CAB12882
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-125 of human TDRD1 (NP_942090.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-125 of human TDRD1 (NP_942090.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PFNF EKNE NKLP PHES LRSP GTLP NHPN FRLK SSEN GNKK NNFL LCEQ TKQY LASQ EDNS VSSN PNGI NGEV VGSK GDRK KLPA GNSV SPPS AESN SPPK E
Gene ID:56165
Uniprot:Q9BXT4
Cellular Location:Cytoplasm
Calculated MW:79kDa/119kDa/132kDa
Observed MW:132kDa
Synonyms:TDRD1, CT41.1
Background:This gene is similar to a mouse gene that encodes a tudor domain protein. Alternatively spliced transcript variants have been described but their full length sequences have not been determined.
UniProt Protein Function:TDRD1: Plays a central role during spermatogenesis by participating in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. Belongs to the TDRD1 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: cytoplasm

Biological Process: DNA methylation during gametogenesis; germ cell development; RNA-mediated gene silencing; spermatogenesis

NCBI Summary:This gene is similar to a mouse gene that encodes a tudor domain protein. Alternatively spliced transcript variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BXT4
NCBI GenInfo Identifier:206729901
NCBI Gene ID:56165
NCBI Accession:Q9BXT4.2
UniProt Secondary Accession:Q9BXT4,Q4G0Y8, Q6P518, Q9H7B3, A6NEN3, A6NMN2, B3KVI4 B4E2L5, D3DRC2,
UniProt Related Accession:Q9BXT4
Molecular Weight:79,170 Da
NCBI Full Name:Tudor domain-containing protein 1
NCBI Synonym Full Names:tudor domain containing 1
NCBI Official Symbol:TDRD1  
NCBI Official Synonym Symbols:CT41.1  
NCBI Protein Information:tudor domain-containing protein 1
UniProt Protein Name:Tudor domain-containing protein 1
UniProt Synonym Protein Names:Cancer/testis antigen 41.1; CT41.1
Protein Family:Tudor domain-containing protein
UniProt Gene Name:TDRD1  
UniProt Entry Name:TDRD1_HUMAN
Anti-TDRD1 Antibody (CAB12882)Western blot analysis of extracts of mouse testis, using TDRD1 Antibody (CAB12882) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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