Signal Transduction Antibodies 3
Anti-TCN1 Antibody (CAB6414)
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- SKU:
- CAB6414
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-TCN1 Antibody |
| Antibody SKU: | CAB6414 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-280 of human TCN1 (NP_001053.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-280 of human TCN1 (NP_001053.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EICE VSEE NYIR LKPL LNTM IQSN YNRG TSAV NVVL SLKL VGIQ IQTL MQKM IQQI KYNV KSRL SDVS SGEL ALII LALG VCRN AEEN LIYD YHLI DKLE NKFQ AEIE NMEA HNGT PLTN YYQL SLDV LALC LFNG NYST AEVV NHFT PENK NYYF GSQF SVDT GAMA VLAL TCVK KSLI NGQI KADE GSLK NISI YTKS LVEK ILSE KKEN GLIG NTFS TGEA MQAL FVSS DYYN ENDW NCQQ TLNT VLTE ISQG A |
| Gene ID: | 6947 |
| Uniprot: | P20061 |
| Cellular Location: | Secreted |
| Calculated MW: | 48kDa |
| Observed MW: | 48kDa |
| Synonyms: | TCN1, HC, TC-1, TC1, TCI |
| Background: | This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. |
| UniProt Protein Function: | TCN1: Vitamin B12-binding protein. Transports cobalamin into cells. Belongs to the eukaryotic cobalamin transport proteins family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q11-q12 Cellular Component: extracellular space; extracellular region Molecular Function:cobalamin binding Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process |
| NCBI Summary: | This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20061 |
| NCBI GenInfo Identifier: | 146345530 |
| NCBI Gene ID: | 6947 |
| NCBI Accession: | P20061.2 |
| UniProt Secondary Accession: | P20061,Q8WV77, A8KAC5, |
| UniProt Related Accession: | P20061 |
| Molecular Weight: | 433 |
| NCBI Full Name: | Transcobalamin-1 |
| NCBI Synonym Full Names: | transcobalamin I (vitamin B12 binding protein, R binder family) |
| NCBI Official Symbol: | TCN1 |
| NCBI Official Synonym Symbols: | HC; TC1; TCI; TC-1 |
| NCBI Protein Information: | transcobalamin-1; protein R; haptocorin; haptocorrin |
| UniProt Protein Name: | Transcobalamin-1 |
| UniProt Synonym Protein Names: | Haptocorrin; HC; Protein R; Transcobalamin I; TC I; TCI |
| Protein Family: | Transcobalamin |
| UniProt Gene Name: | TCN1 |
| UniProt Entry Name: | TCO1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TCN1 antibody (CAB6414) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of MCF7 cells using TCN1 antibody (CAB6414). Blue: DAPI for nuclear staining. |
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