Epigenetics & Nuclear Signaling Antibodies 1

Anti-TBX2 Antibody (CAB10250)

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SKU:
CAB10250
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-TBX2 Antibody
Antibody SKU:CAB10250
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-470 of human TBX2 (NP_005985.3).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-470 of human TBX2 (NP_005985.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TLPS LRLY EEHC KPER DGAE SDAS SCDP PPAR EPPT SPGA APSP LRLH RARA EEKS CAAD SDPE PERL SEER AGAP LGRS PAPD SASP TRLT EPER ARER RSPE RGKE PAES GGDG PFGL RSLE KERA EARR KDEG RKEA AEGK EQGL APLV VQTD SASP LGAG HLPG LAF
Gene ID:6909
Uniprot:Q13207
Cellular Location:Nucleus
Calculated MW:75kDa
Observed MW:75kDa
Synonyms:TBX2, T-box 2
Background:This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
UniProt Protein Function:TBX2: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: nucleus

Molecular Function:DNA binding; protein binding; sequence-specific DNA binding

Biological Process: cardiac muscle development; cell aging; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic heart tube development; heart looping; muscle cell fate determination; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation; regulation of heart contraction

NCBI Summary:This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q13207
NCBI GenInfo Identifier:294862490
NCBI Gene ID:6909
NCBI Accession:Q13207.3
UniProt Secondary Accession:Q13207,Q16424, Q7Z647,
UniProt Related Accession:Q13207
Molecular Weight:75,066 Da
NCBI Full Name:T-box transcription factor TBX2
NCBI Synonym Full Names:T-box 2
NCBI Official Symbol:TBX2  
NCBI Protein Information:T-box transcription factor TBX2
UniProt Protein Name:T-box transcription factor TBX2
Protein Family:T-box transcription factor
UniProt Gene Name:TBX2  
UniProt Entry Name:TBX2_HUMAN
Anti-TBX2 Antibody (CAB10250)Western blot analysis of extracts of MCF-7 cells, using TBX2 antibody (CAB10250) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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