Metabolism Antibodies 3

Anti-TAX1BP3 Antibody (CAB8750)

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SKU:
CAB8750
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-TAX1BP3 Antibody
Antibody SKU:CAB8750
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human TAX1BP3 (NP_055419.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human TAX1BP3 (NP_055419.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSYI PGQP VTAV VQRV EIHK LRQG ENLI LGFS IGGG IDQD PSQN PFSE DKTD KGIY VTRV SEGG PAEI AGLQ IGDK IMQV NGWD MTMV THDQ ARKR LTKR SEEV VRLL VTRQ SLQK AVQQ SMLS
Gene ID:30851
Uniprot:O14907
Cellular Location:Cell membrane, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein
Calculated MW:13kDa
Observed MW:14kDa
Synonyms:TAX1BP3, TIP-1, TIP1
Background:This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniProt Protein Function:TAX1BP3: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
UniProt Protein Details:

Protein type:Cell cycle regulation; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: cytosol

Molecular Function:protein binding; protein C-terminus binding

Biological Process: negative regulation of Wnt receptor signaling pathway; Rho protein signal transduction

UniProt Code:O14907
NCBI GenInfo Identifier:74739481
NCBI Gene ID:30851
NCBI Accession:O14907.2
UniProt Secondary Accession:O14907,Q7LCQ4, B2RD53, D3DTJ6,
UniProt Related Accession:O14907
Molecular Weight:13,735 Da
NCBI Full Name:Tax1-binding protein 3
NCBI Synonym Full Names:Tax1 binding protein 3
NCBI Official Symbol:TAX1BP3  
NCBI Official Synonym Symbols:TIP1; TIP-1  
NCBI Protein Information:tax1-binding protein 3
UniProt Protein Name:Tax1-binding protein 3
UniProt Synonym Protein Names:Glutaminase-interacting protein 3; Tax interaction protein 1; TIP-1; Tax-interacting protein 1
UniProt Gene Name:TAX1BP3  
UniProt Entry Name:TX1B3_HUMAN
Anti-TAX1BP3 Polyclonal Antibody (CAB8750)Western blot analysis of extracts of various cell lines, using TAX1BP3 antibody (CAB8750) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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