Anti-TASK-1 Antibody [N374/48 (Formerly sold as S374-48)]

TASK-1 Antibody [N374/48 (Formerly sold as S374-48)]

TASK-1 Antibody [N374/48 (Formerly sold as S374-48)] is a mouse monoclonal antibody directed against TASK-1, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2b, purified by Protein G.

TASK-1 (TWIK-related acid-sensitive K+ channel 1) is a member of the two-pore domain potassium (K2P) channel family, characterized by four transmembrane segments and two pore-forming domains. These channels contribute to background (leak) potassium currents that stabilize the resting membrane potential and regulate neuronal excitability. TASK-1 is highly sensitive to extracellular pH within the physiological range, making it a dynamic modulator of neuronal activity in response to metabolic and environmental changes. TASK-1 is prominently expressed in the brain and heart, with particularly high levels in the right atrium and various central nervous system regions. Its ability to respond to subtle shifts in pH positions TASK-1 as a key player in maintaining ionic homeostasis and protecting neurons under stress conditions, such as ischemia, inflammation, and oxidative damage—hallmarks of neurodegenerative diseases. Recent research suggests that dysregulation of TASK-1 may contribute to altered neuronal excitability, impaired synaptic transmission, and neuroinflammation in disorders such as Alzheimer’s disease, Parkinson’s disease, and epilepsy. Moreover, TASK-1’s role in modulating glial cell function and neurovascular coupling further underscores its relevance in brain health and disease. As a pH-sensitive ion channel with broad regulatory functions, TASK-1 represents a promising therapeutic target for restoring neuronal stability and mitigating neurodegenerative processes. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.