Signal Transduction Antibodies 2
Anti-TAS2R10 Antibody (CAB15156)
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- SKU:
- CAB15156
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-TAS2R10 Antibody |
| Antibody SKU: | CAB15156 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TAS2R10 (NP_076410.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TAS2R10 (NP_076410.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TSLS IFYF LKIA NFSN YIFL WLKS RTNM VLPF MIVF LLIS SLLN FAYI AKIL NDYK TKND TVWD LNMY KSEY FIKQ ILLN LGVI FFFT LSLI TCIF LIIS L |
| Gene ID: | 50839 |
| Uniprot: | Q9NYW0 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 35kDa |
| Observed MW: | 37kDa |
| Synonyms: | TAS2R10, T2R10, TRB2 |
| Background: | This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. |
| UniProt Protein Function: | TAS2R10: Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium- regulated cation channel TRPM5. Belongs to the G-protein coupled receptor T2R family. |
| UniProt Protein Details: | Protein type:GPCR, T2R family; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12p13 Cellular Component: integral to membrane; plasma membrane Molecular Function:bitter taste receptor activity; taste receptor activity Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste |
| NCBI Summary: | This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NYW0 |
| NCBI GenInfo Identifier: | 311033532 |
| NCBI Gene ID: | 50839 |
| NCBI Accession: | Q9NYW0.3 |
| UniProt Secondary Accession: | Q9NYW0,Q3MIM9, Q6NTD9, |
| UniProt Related Accession: | Q9NYW0 |
| Molecular Weight: | 35,365 Da |
| NCBI Full Name: | Taste receptor type 2 member 10 |
| NCBI Synonym Full Names: | taste 2 receptor member 10 |
| NCBI Official Symbol: | TAS2R10 |
| NCBI Official Synonym Symbols: | TRB2; T2R10 |
| NCBI Protein Information: | taste receptor type 2 member 10 |
| UniProt Protein Name: | Taste receptor type 2 member 10 |
| UniProt Synonym Protein Names: | Taste receptor family B member 2; TRB2 |
| Protein Family: | Taste receptor |
| UniProt Gene Name: | TAS2R10 |
| UniProt Entry Name: | T2R10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TAS2R10 antibody (CAB15156) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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