Neuroscience

Anti-SV2B Antibody (CAB16269)

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SKU:
CAB16269
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Neuroscience

Description

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Antibody Name:Anti-SV2B Antibody
Antibody SKU:CAB16269
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 415-540 of human SV2B (NP_055663.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 415-540 of human SV2B (NP_055663.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IRYF QDEE YKSK MKVF FGEH VYGA TINF TMEN QIHQ HGKL VNDK FTRM YFKH VLFE DTFF DECY FEDV TSTD TYFK NCTI ESTI FYNT DLYE HKFI NCRF INST FLEQ KEGC HMDL EQDN DFLI YL
Gene ID:9899
Uniprot:Q7L1I2
Cellular Location:
Calculated MW:60kDa/77kDa
Observed MW:Refer to figures
Synonyms:SV2B, HsT19680
Background:This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients.
UniProt Protein Function:SV2B: Probably plays a role in the control of regulated secretion in neural and endocrine cells. Belongs to the major facilitator superfamily.
UniProt Protein Details:

Protein type:Vesicle; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: synaptic vesicle; membrane; synaptic vesicle membrane; integral to membrane; plasma membrane; acrosome; cell junction

Molecular Function:transmembrane transporter activity

Biological Process: neurotransmitter transport; pathogenesis; transmembrane transport

UniProt Code:Q7L1I2
NCBI GenInfo Identifier:262399383
NCBI Gene ID:9899
NCBI Accession:NP_001161052.1
UniProt Secondary Accession:Q7L1I2,O94840, Q6IAR8, B4DH30, C6G489,
UniProt Related Accession:Q7L1I2
Molecular Weight:77,444 Da
NCBI Full Name:synaptic vesicle glycoprotein 2B isoform 2
NCBI Synonym Full Names:synaptic vesicle glycoprotein 2B
NCBI Official Symbol:SV2B  
NCBI Official Synonym Symbols:HsT19680  
NCBI Protein Information:synaptic vesicle glycoprotein 2B; synaptic vesicle protein 2B homolog
UniProt Protein Name:Synaptic vesicle glycoprotein 2B
Protein Family:Synaptic vesicle glycoprotein
UniProt Gene Name:SV2B  
UniProt Entry Name:SV2B_HUMAN
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