Neuroscience
Anti-SV2A Antibody (CAB17868)
- SKU:
- CAB17868
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-SV2A Antibody |
| Antibody SKU: | CAB17868 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 356-447 of human SV2A (NP_055664.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse kidney, Mouse heart, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 356-447 of human SV2A (NP_055664.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ESPR FFLE NGKH DEAW MVLK QVHD TNMR AKGH PERV FSVT HIKT IHQE DELI EIQS DTGT WYQR WGVR ALSL GGQV WGNF LSCF GPEY RRIT |
| Gene ID: | 9900 |
| Uniprot: | Q7L0J3 |
| Cellular Location: | |
| Calculated MW: | 83kDa |
| Observed MW: | 105kDa |
| Synonyms: | SV2, SV2A |
| Background: | The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. |
| UniProt Protein Function: | SV2A: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. Belongs to the major facilitator superfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Vesicle Chromosomal Location of Human Ortholog: 1q21.2 Cellular Component: synaptic vesicle; neuron projection; synaptic vesicle membrane; endoplasmic reticulum; cytoplasm; plasma membrane; presynaptic active zone; integral to membrane; intercellular junction; neuromuscular junction Molecular Function:receptor activity; transmembrane transporter activity; protein kinase binding Biological Process: cellular calcium ion homeostasis; neurotransmitter transport; pathogenesis; transmembrane transport |
| UniProt Code: | Q7L0J3 |
| NCBI GenInfo Identifier: | 523498712 |
| NCBI Gene ID: | 9900 |
| NCBI Accession: | NP_001265648.1 |
| UniProt Secondary Accession: | Q7L0J3,O94841, Q5QNX8, Q7Z3L6, Q8NBJ6, Q9BVZ9, D3DUZ7 |
| UniProt Related Accession: | Q7L0J3 |
| Molecular Weight: | 82,695 Da |
| NCBI Full Name: | synaptic vesicle glycoprotein 2A isoform 2 |
| NCBI Synonym Full Names: | synaptic vesicle glycoprotein 2A |
| NCBI Official Symbol: | SV2A |
| NCBI Official Synonym Symbols: | SV2 |
| NCBI Protein Information: | synaptic vesicle glycoprotein 2A |
| UniProt Protein Name: | Synaptic vesicle glycoprotein 2A |
| Protein Family: | Synaptic vesicle glycoprotein |
| UniProt Gene Name: | SV2A |
| UniProt Entry Name: | SV2A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SV2A antibody (CAB17868) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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