Anti-SUPT5H/SPT5 Antibody (CAB19225)
- SKU:
- CAB19225
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- SUPT5H
- Synonyms:
- SPT5
- Synonyms:
- SPT5H
- Synonyms:
- Tat-CT1
- Synonyms:
- transcription elongation factor SPT5
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | SUPT5H/SPT5 Rabbit mAb |
| Product Code: | CAB19225 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | SUPT5H, SPT5, SPT5H, Tat-CT1, transcription elongation factor SPT5 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SUPT5H/SPT5. |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant protein of human SUPT5H/SPT5. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6829 |
| Uniprot: | O00267 |
| Cellular Location: | Nucleus |
| Calculated MW: | 155kDa |
| Observed MW: | 150kDa |
| UniProt Protein Function: | SPT5: a transcription elongation factor. Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Two alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:RNA-binding; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 19q13 Cellular Component: nucleoplasm; nucleus Molecular Function:enzyme binding; protein binding; protein heterodimerization activity Biological Process: mRNA capping; negative regulation of RNA elongation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of macroautophagy; positive regulation of RNA elongation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of viral transcription; response to organic substance; RNA elongation; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| UniProt Code: | O00267 |
| NCBI GenInfo Identifier: | 74735318 |
| NCBI Gene ID: | 6829 |
| NCBI Accession: | O00267.1 |
| UniProt Secondary Accession: | O00267,O43279, Q59G52, Q99639, |
| UniProt Related Accession: | O00267 |
| Molecular Weight: | 120,499 Da |
| NCBI Full Name: | Transcription elongation factor SPT5 |
| NCBI Synonym Full Names: | SPT5 homolog, DSIF elongation factor subunit |
| NCBI Official Symbol: | SUPT5H |
| NCBI Official Synonym Symbols: | SPT5; SPT5H; Tat-CT1 |
| NCBI Protein Information: | transcription elongation factor SPT5 |
| UniProt Protein Name: | Transcription elongation factor SPT5 |
| UniProt Synonym Protein Names: | DRB sensitivity-inducing factor 160 kDa subunit; DSIF p160; DRB sensitivity-inducing factor large subunit; DSIF large subunit; Tat-cotransactivator 1 protein; Tat-CT1 protein |
| UniProt Gene Name: | SUPT5H |
| UniProt Entry Name: | SPT5H_HUMAN |
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