Neuroscience

Anti-STX4 Antibody (CAB4133)

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SKU:
CAB4133
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Neuroscience

Description

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Antibody Name:Anti-STX4 Antibody
Antibody SKU:CAB4133
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human STX4 (NP_004595.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HL-60, A375, COS-1, NIH/3T3, MCF7, NCI-H460, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human STX4 (NP_004595.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRDR THEL RQGD DSSD EEDK ERVA LVVH PGTA RLGS PDEE FFHK VRTI RQTI VKLG NKVQ ELEK QQVT ILAT PLPE ESMK QELQ NLRD EIKQ LGRE IRLQ LKAI EPQK EEAD ENYN SVNT RMRK TQHG VLSQ QFVE LINK CNSM QSEY REKN VERI RRQL KITN AGMV SDEE LEQM LDSG QSEV FVSN ILKD TQVT RQAL NEIS ARHS EIQQ LERS IREL HDIF TFLA TEVE MQGE MINR IEKN ILSS ADYV ERGQ EHVK TALE NQKK ARKK KVL
Gene ID:6810
Uniprot:Q12846
Cellular Location:Cell membrane, Single-pass type IV membrane protein
Calculated MW:33kDa/34kDa
Observed MW:37kDa
Synonyms:STX4, STX4A, p35-2
Background:
UniProt Protein Function:STX4: a protein of the syntaxin/epimorphin family. Contains 1 t-SNARE coiled-coil homology domain. Potentially involved in docking of synaptic vesicles at presynaptic active zones. Interacts with SNAP23 and SNAP25BP. Found in a complex with VAMP8 and SNAP23 in pancreas.
UniProt Protein Details:

Protein type:Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: extracellular space; specific granule; cell surface; lateral loop; basolateral plasma membrane; integral to membrane; dendritic spine; trans-Golgi network; cytosol; SNARE complex; synaptic vesicle; membrane; perinuclear region of cytoplasm; lamellipodium; plasma membrane; vacuole; synapse; intracellular; endosome

Molecular Function:sphingomyelin phosphodiesterase activator activity; SNAP receptor activity; SNARE binding; protein binding

Biological Process: positive regulation of catalytic activity; platelet activation; positive regulation of cell adhesion; organelle fusion; positive regulation of eosinophil degranulation; positive regulation of chemotaxis; positive regulation of immunoglobulin secretion; synaptic vesicle fusion to presynaptic membrane; regulation of exocytosis; intracellular protein transport; response to hydroperoxide; vesicle docking; positive regulation of cell proliferation; post-Golgi vesicle-mediated transport; blood coagulation; positive regulation of cell migration

UniProt Code:Q12846
NCBI GenInfo Identifier:3041737
NCBI Gene ID:6810
NCBI Accession:Q12846.2
UniProt Secondary Accession:Q12846,Q3SWZ3, P70452, Q08850,
UniProt Related Accession:Q12846
Molecular Weight:34180
NCBI Full Name:Syntaxin-4
NCBI Synonym Full Names:syntaxin 4
NCBI Official Symbol:STX4  
NCBI Official Synonym Symbols:STX4A; p35-2  
NCBI Protein Information:syntaxin-4
UniProt Protein Name:Syntaxin-4
UniProt Synonym Protein Names:Renal carcinoma antigen NY-REN-31
UniProt Gene Name:STX4  
UniProt Entry Name:STX4_HUMAN
Anti-STX4 Antibody (CAB4133)Western blot analysis of extracts of various cell lines, using STX4 antibody (CAB4133) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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