KO Validated Antibodies 2

Anti-STRAP Antibody (CAB19989)[KO Validated]

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SKU:
CAB19989
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-STRAP Antibody [KO Validated]
Antibody SKU:CAB19989
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human STRAP.
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant protein of human STRAP.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:11171
Uniprot:Q9Y3F4
Cellular Location:Cytoplasm, Nucleus
Calculated MW:38kDa/39kDa
Observed MW:39KDa
Anti-STRAP Antibody [KO Validated] (CAB19989)Western blot analysis of extracts from normal (control) and STRAP knockout (KO) 293T cells, using STRAP antibody (CAB19989) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:STRAP, MAWD, PT-WD, UNRIP
Background:
UniProt Protein Function:STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family.
UniProt Protein Details:

Protein type:RNA splicing; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; SMN complex; nucleus; cytosol

Molecular Function:protein binding; receptor binding

Biological Process: spliceosomal snRNP biogenesis; transforming growth factor beta receptor signaling pathway; maintenance of gastrointestinal epithelium; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of epithelial cell proliferation

UniProt Code:Q9Y3F4
NCBI GenInfo Identifier:12643951
NCBI Gene ID:11171
NCBI Accession:Q9Y3F4.1
UniProt Secondary Accession:Q9Y3F4,Q5TZT4, Q9NTK0, Q9UQC8, B2R5S5, B4DNJ6,
UniProt Related Accession:Q9Y3F4
Molecular Weight:350
NCBI Full Name:Serine-threonine kinase receptor-associated protein
NCBI Synonym Full Names:serine/threonine kinase receptor associated protein
NCBI Official Symbol:STRAP  
NCBI Official Synonym Symbols:MAWD; PT-WD; UNRIP  
NCBI Protein Information:serine-threonine kinase receptor-associated protein; unr-interacting protein; WD-40 repeat protein PT-WD; MAP activator with WD repeats
UniProt Protein Name:Serine-threonine kinase receptor-associated protein
UniProt Synonym Protein Names:MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD
Protein Family:Serine-threonine kinase receptor-associated protein
UniProt Gene Name:STRAP  
UniProt Entry Name:STRAP_HUMAN
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