Cell Cycle Antibodies 1
Anti-STRADA Antibody (CAB10336)
- SKU:
- CAB10336
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Antibody Name: | Anti-STRADA Antibody |
Antibody SKU: | CAB10336 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-210 of human STRADA (NP_699166.2). |
Application: | WB |
Recommended Dilution: | WB 1:1000 - 1:2000 |
Reactivity: | Mouse |
Positive Samples: | Mouse skeletal muscle |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-210 of human STRADA (NP_699166.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | FLPE GGCY ELLT VIGK GFED LMTV NLAR YKPT GEYV TVRR INLE ACSN EMVT FLQG ELHV SKLF NHPN IVPY RATF IADN ELWV VTSF MAYG SAKD LICT HFMD GMNE LAIA YILQ GVLK ALDY IHHM GYVH RSVK ASHI LISV DGKV YLSG LRSN LSMI SHGQ RQRV VHDF PKYS VKVL PWLS PE |
Gene ID: | 92335 |
Uniprot: | Q7RTN6 |
Cellular Location: | Cytoplasm, Nucleus |
Calculated MW: | 33kDa/34kDa/38kDa/41kDa/43kDa/48kDa |
Observed MW: | 48kDa |
Synonyms: | STRADA, LYK5, NY-BR-96, PMSE, STRAD, Stlk |
Background: | The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. |
UniProt Protein Function: | STRAD: a pseudokinase which, in complex with CAB39, binds to and activates LKB1. Relocates LKB1 from the nucleus to the cytoplasm. Plays an essential role in LKB1-mediated G1 cell cycle arrest. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; STLK subfamily Chromosomal Location of Human Ortholog: 17q23.3 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:kinase binding; protein binding; protein kinase activator activity; protein kinase activity; protein serine/threonine kinase activator activity Biological Process: activation of protein kinase activity; cell cycle arrest; protein amino acid phosphorylation; protein export from nucleus Disease: Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy |
NCBI Summary: | The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009] |
UniProt Code: | Q7RTN6 |
NCBI GenInfo Identifier: | 74759034 |
NCBI Gene ID: | 92335 |
NCBI Accession: | Q7RTN6.1 |
UniProt Secondary Accession: | Q7RTN6,Q5JPI2, Q7Z4K9, Q8NC31, Q8NCF1, Q9H272, B4DDE3 B4DW17, J3KTC9, |
UniProt Related Accession: | Q7RTN6 |
Molecular Weight: | 34,625 Da |
NCBI Full Name: | STE20-related kinase adapter protein alpha |
NCBI Synonym Full Names: | STE20-related kinase adaptor alpha |
NCBI Official Symbol: | STRADA |
NCBI Official Synonym Symbols: | LYK5; PMSE; Stlk; STRAD; NY-BR-96 |
NCBI Protein Information: | STE20-related kinase adapter protein alpha |
UniProt Protein Name: | STE20-related kinase adapter protein alpha |
UniProt Synonym Protein Names: | STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96 |
UniProt Gene Name: | STRADA |
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