Anti-Steroidogenic factor-1 (SF-1/NR5A1) Antibody (CAB19277)

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CAB19277

Description

Product Name:Steroidogenic factor-1 (SF-1/NR5A1) Rabbit mAb
Product Code:CAB19277
Size:20uL, 50uL, 100uL
Synonyms:NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3, hSF-1, SRXX4, steroidogenic factor 1
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human Steroidogenic factor-1 (SF-1/NR5A1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, Mouse ovary, Mouse spleen
Immunogen:Recombinant protein of human Steroidogenic factor-1 (SF-1/NR5A1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2516
Uniprot:Q13285
Cellular Location:Nucleus
Calculated MW:52kDa
Observed MW:50KDa
UniProt Protein Function:STF-1: a nuclear hormone receptor of the NR5 subfamily. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes.
UniProt Protein Details:

Protein type:Nuclear receptor

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: nucleoplasm; nucleus

Molecular Function:chromatin binding; DNA binding; enzyme binding; ligand-dependent nuclear receptor activity; phospholipid binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity

Biological Process: cell-cell signaling; hormone-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; primary sex determination; regulation of steroid biosynthetic process; tissue development; transcription initiation from RNA polymerase II promoter

Disease: 46,xy Sex Reversal 3; Premature Ovarian Failure 7; Spermatogenic Failure 8

NCBI Summary:The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]
UniProt Code:Q13285
NCBI GenInfo Identifier:3121738
NCBI Gene ID:2516
NCBI Accession:Q13285.2
UniProt Secondary Accession:Q13285,O15196, Q5T6F5,
UniProt Related Accession:Q13285
Molecular Weight:51,636 Da
NCBI Full Name:Steroidogenic factor 1
NCBI Synonym Full Names:nuclear receptor subfamily 5 group A member 1
NCBI Official Symbol:NR5A1  
NCBI Official Synonym Symbols:ELP; SF1; FTZ1; POF7; SF-1; AD4BP; FTZF1; SPGF8; SRXY3; hSF-1  
NCBI Protein Information:steroidogenic factor 1
UniProt Protein Name:Steroidogenic factor 1
UniProt Synonym Protein Names:Adrenal 4-binding protein; Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; Steroid hormone receptor Ad4BP
Protein Family:Steroidogenic factor
UniProt Gene Name:NR5A1  
UniProt Entry Name:STF1_HUMAN
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Additional Information

Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NR5A1
Synonyms:
AD4BP
Synonyms:
ELP
Synonyms:
FTZ1
Synonyms:
FTZF1
Synonyms:
POF7
Synonyms:
SF-1
Synonyms:
SF1
Synonyms:
SPGF8
Synonyms:
SRXY3
Synonyms:
hSF-1
Synonyms:
SRXX4
Synonyms:
steroidogenic factor 1
Research Area:
Epigenetics and Nuclear Signaling
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