Cell Death Antibodies 1

Anti-STEAP3 Antibody (CAB0683)

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SKU:
CAB0683
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-STEAP3 Antibody
Antibody SKU:CAB0683
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human STEAP3 (NP_060704.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human STEAP3 (NP_060704.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPEE MDKP LISL HLVD SDSS LAKV PDEA PKVG ILGS GDFA RSLA TRLV GSGF KVVV GSRN PKRT ARLF PSAA QVTF QEEA VSSP EVIF VAVF REHY SSLC SLSD QLAG KILV DVSN PTEQ EHLQ HRES NAEY LASL FPTC TVVK AFNV ISAW TLQA GPRD GNRQ VPIC GDQP EAKR AVSE
Gene ID:55240
Uniprot:Q658P3
Cellular Location:Endosome membrane, Multi-pass membrane protein
Calculated MW:50kDa/54kDa/55kDa
Observed MW:55kDa
Synonyms:STEAP3, AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde
Background:This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:STEAP3: a multi-pass membrane protein induced directly by p53. Plays an important role in facilitating exosome secretion. Enhances secretion in the DNA damage-induced p53-dependent exosomal secretory pathway. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. Highly expressed in hematopoietic tissues where it localizes to the specialized endosome. An endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor. Contains a highly-conserved tyrosine-based motif that has been shown to target transmembrane proteins, including LAMP-1, LAMP-2, the TfR, and SLC11A1 to endosomes, lysosomes, and lysosome-related organelles. Facilitates the exosomal secretion of proteins such as TCTP. Interacts with BNIP3L, MYT1 and TPT1. Four human isoforms are produced by alternative splicing. Isoform 4 is also known as pHyde II.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; EC 1.16.1.-; Transporter, iron; Transporter, ion channel; Oxidoreductase; Transporter

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: multivesicular body; integral to membrane; plasma membrane; endosome membrane

Molecular Function:protein binding; metal ion binding; cupric reductase activity; ferric-chelate reductase activity

Biological Process: apoptosis; cellular iron ion homeostasis; protein secretion; transferrin transport; copper ion import; cell cycle; transmembrane transport

Disease: Anemia, Hypochromic Microcytic, With Iron Overload 2

NCBI Summary:This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
UniProt Code:Q658P3
NCBI GenInfo Identifier:146325737
NCBI Gene ID:55240
NCBI Accession:Q658P3.2
UniProt Secondary Accession:Q658P3,Q4VBR2, Q4ZG36, Q53SQ8, Q7Z389, Q86SF6, Q8NEW6 Q8TDP3, Q8TF03, Q9NVB5, A8K6E3,
UniProt Related Accession:Q658P3
Molecular Weight:488
NCBI Full Name:Metalloreductase STEAP3
NCBI Synonym Full Names:STEAP family member 3, metalloreductase
NCBI Official Symbol:STEAP3  
NCBI Official Synonym Symbols:STMP3; TSAP6; AHMIO2; dudlin-2  
NCBI Protein Information:metalloreductase STEAP3; pHyde; hTSAP6; hpHyde; dudlin 2; dudulin 2; dudulin-2; 1010001D01Rik; tumor suppressor pHyde; six transmembrane prostate protein 3; tumor suppressor-activated pathway protein 6; six-transmembrane epithelial antigen of prostate 3
UniProt Protein Name:Metalloreductase STEAP3
UniProt Synonym Protein Names:Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde
Protein Family:Metalloreductase
UniProt Gene Name:STEAP3  
UniProt Entry Name:STEA3_HUMAN
Anti-STEAP3 Antibody (CAB0683)Western blot analysis of extracts of mouse heart, using STEAP3 antibody (CAB0683) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
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