Cell Biology Antibodies 1
Anti-STAR Antibody (CAB1035)
- SKU:
- CAB1035
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-STAR Antibody |
| Antibody SKU: | CAB1035 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IP |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 64-285 of human STAR (NP_000340.2). |
| Application: | WB IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 64-285 of human STAR (NP_000340.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EETL YSDQ ELAY LQQG EEAM QKAL GILS NQEG WKKE SQQD NGDK VMSK VVPD VGKV FRLE VVVD QPME RLYE ELVE RMEA MGEW NPNV KEIK VLQK IGKD TFIT HELA AEAA GNLV GPRD FVSV RCAK RRGS TCVL AGMA TDFG NMPE QKGV IRAE HGPT CMVL HPLA GSPS KTKL TWLL SIDL KGWL PKSI INQV LSQT QVDF ANHL RKRL ESHP ASEA RC |
| Gene ID: | 6770 |
| Uniprot: | P49675 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 31kDa |
| Observed MW: | 28kDa |
| Synonyms: | STAR, STARD1, STAR |
| Background: | The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. |
| UniProt Protein Function: | STAR: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. May interact with TSPO. Expressed in gonads, adrenal cortex and kidney. |
| UniProt Protein Details: | Protein type:Mitochondrial; Lipid-binding; Carrier Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: mitochondrial crista; neuron projection; cell soma; mitochondrial intermembrane space; cytosol Molecular Function:cholesterol transporter activity; cholesterol binding Biological Process: response to nicotine; steroid metabolic process; diterpenoid metabolic process; dibenzo-p-dioxin metabolic process; regulation of steroid biosynthetic process; estrogen biosynthetic process; biphenyl metabolic process; circadian sleep/wake cycle, REM sleep; negative regulation of neuron apoptosis; response to nutrient; response to corticosterone stimulus; response to drug; cholesterol metabolic process; bile acid biosynthetic process; positive regulation of neurogenesis; insecticide metabolic process; progesterone biosynthetic process; fractalkine metabolic process; male gonad development; phthalate metabolic process; intracellular cholesterol transport; response to herbicide; glucocorticoid metabolic process; response to ethanol; response to hydrogen peroxide; cellular response to insulin stimulus; response to estrogen stimulus; response to lead ion; C21-steroid hormone biosynthetic process; brain development; response to activity; response to ionizing radiation; steroid biosynthetic process; regulation of neuronal synaptic plasticity; phenol metabolic process Disease: Lipoid Congenital Adrenal Hyperplasia |
| NCBI Summary: | The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49675 |
| NCBI GenInfo Identifier: | 71152974 |
| NCBI Gene ID: | 6770 |
| NCBI Accession: | P49675.2 |
| UniProt Secondary Accession: | P49675,Q16396, |
| UniProt Related Accession: | P49675 |
| Molecular Weight: | 285 |
| NCBI Full Name: | Steroidogenic acute regulatory protein, mitochondrial |
| NCBI Synonym Full Names: | steroidogenic acute regulatory protein |
| NCBI Official Symbol: | STAR |
| NCBI Official Synonym Symbols: | STARD1 |
| NCBI Protein Information: | steroidogenic acute regulatory protein, mitochondrial; cholesterol trafficker; START domain containing 1; steroid acute regulatory protein; START domain-containing protein 1; mitochondrial steroid acute regulatory protein; StAR-related lipid transfer (START) domain containing 1 |
| UniProt Protein Name: | Steroidogenic acute regulatory protein, mitochondrial |
| UniProt Synonym Protein Names: | START domain-containing protein 1; StARD1 |
| Protein Family: | Starch synthase |
| UniProt Gene Name: | STAR |
| UniProt Entry Name: | STAR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STAR antibody (CAB1035) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). |
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