Cell Biology Antibodies 16

Anti-SSH2 Antibody (CAB9988)

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SKU:
CAB9988
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SSH2 Antibody
Antibody SKU:CAB9988
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 53-202 of human SSH2 (NP_001269060.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 53-202 of human SSH2 (NP_001269060.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GAAL FLPR GNGS STPR ISHR RNKH AGDL QQHL QAMF ILLR PEDN IRLA VRLE STYQ NRTR YMVV VSTN GRQD TEES IVLG MDFS SNDS STCT MGLV LPLW SDTL IHLD GDGG FSVS TDNR VHIF KPVS VQAM WVDR DSRN KHCD VLLV EE
Gene ID:85464
Uniprot:Q76I76
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:21kDa/22kDa/51kDa/158kDa
Observed MW:158kDa
Synonyms:SSH2, SSH-2, SSH-2L
Background:This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
UniProt Protein Details:
NCBI Summary:This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Code:Q76I76
NCBI GenInfo Identifier:530788323
NCBI Gene ID:85464
NCBI Accession:NP_001269058.1
UniProt Secondary Accession:Q76I76,Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8
UniProt Related Accession:Q76I76
Molecular Weight:
NCBI Full Name:protein phosphatase Slingshot homolog 2 isoform 1
NCBI Synonym Full Names:slingshot protein phosphatase 2
NCBI Official Symbol:SSH2  
NCBI Official Synonym Symbols:SSH-2; SSH-2L  
NCBI Protein Information:protein phosphatase Slingshot homolog 2
UniProt Protein Name:Protein phosphatase Slingshot homolog 2
UniProt Synonym Protein Names:SSH-like protein 2; SSH-2L; hSSH-2L
Protein Family:Protein phosphatase Slingshot
UniProt Gene Name:SSH2  
UniProt Entry Name:
Anti-SSH2 Polyclonal Antibody (CAB9988)Western blot analysis of extracts of Mouse liver, using SSH2 antibody (CAB9988) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5min.
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