| UniProt Protein Function: | Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. |
| NCBI Summary: | This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31213 |
| NCBI GenInfo Identifier: | 39812447 |
| NCBI Gene ID: | 6716 |
| NCBI Accession: | NP_000339.2 |
| UniProt Secondary Accession: | P31213,Q2M1R4, Q9BYE6, B2RE87, |
| UniProt Related Accession: | P31213 |
| Molecular Weight: | 27 |
| NCBI Full Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
| NCBI Synonym Full Names: | steroid 5 alpha-reductase 2 |
| NCBI Official Symbol: | SRD5A2 |
| NCBI Protein Information: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
| UniProt Protein Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
| UniProt Synonym Protein Names: | 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; S5AR 2; Type II 5-alpha reductase |
| UniProt Gene Name: | SRD5A2 |
