Developmental Biology
Anti-SRD5A1 Antibody (CAB14787)
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- SKU:
- CAB14787
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-SRD5A1 Antibody |
| Antibody SKU: | CAB14787 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SRD5A1 (NP_001038.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse liver, Mouse testis, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SRD5A1 (NP_001038.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LIYP FLMR GGKP MPLL ACTM AIMF CTCN GYLQ SRYL SHCA VYAD DWVT DPRF LIGF GLWL TGML INIH SDHI LRNL RKPG DTGY KIPR GGLF EYVT AANY F |
| Gene ID: | 6715 |
| Uniprot: | P18405 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Multi-pass membrane protein |
| Calculated MW: | 29kDa |
| Observed MW: | 29kDa |
| Synonyms: | SRD5A1, S5AR 1, S5AR1 |
| Background: |
| UniProt Protein Function: | Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. |
| NCBI Summary: | Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008] |
| UniProt Code: | P18405 |
| NCBI GenInfo Identifier: | 4507201 |
| NCBI Gene ID: | 6715 |
| NCBI Accession: | NP_001038.1 |
| UniProt Secondary Accession: | P18405,Q9UHY4, Q9UP36, Q9UP37, B2R7Q1, |
| UniProt Related Accession: | P18405 |
| Molecular Weight: | 28 |
| NCBI Full Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform 1 |
| NCBI Synonym Full Names: | steroid 5 alpha-reductase 1 |
| NCBI Official Symbol: | SRD5A1 |
| NCBI Official Synonym Symbols: | S5AR 1 |
| NCBI Protein Information: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
| UniProt Protein Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
| UniProt Synonym Protein Names: | SR type 1; Steroid 5-alpha-reductase 1; S5AR 1 |
| UniProt Gene Name: | SRD5A1 |
 | Western blot analysis of extracts of various cell lines, using SRD5A1 antibody (CAB14787) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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