Developmental Biology

Anti-SOX6 Antibody (CAB7115)

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SKU:
CAB7115
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-SOX6 Antibody
Antibody SKU:CAB7115
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-74 of human SOX6 (NP_001139291.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HT-29, Jurkat, Mouse kidney, Mouse skeletal muscle, Rat kidney, Rat skeletal muscle
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-74 of human SOX6 (NP_001139291.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKGH GELQ GHER RMSS KQAT SPFA CAAD GEDA MTQD LTSR EKEE GSDQ HVAS HLPL HPIM HNKP HSEE LPTL VS
Gene ID:55553
Uniprot:P35712
Cellular Location:Nucleus
Calculated MW:88kDa/89kDa/91kDa
Observed MW:110kDa
Synonyms:SOX6, HSSOX6, SOXD, SRY-box 6
Background:This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.
NCBI Summary:This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
UniProt Code:P35712
NCBI GenInfo Identifier:1541310033
NCBI Gene ID:55553
NCBI Accession:NP_059978
UniProt Related Accession:P35712
Molecular Weight:89kDa
NCBI Full Name:transcription factor SOX-6 isoform b
NCBI Synonym Full Names:SRY-box 6
NCBI Official Symbol:SOX6  
NCBI Official Synonym Symbols:SOXD; HSSOX6  
NCBI Protein Information:transcription factor SOX-6
UniProt Protein Name:
Protein Family:Transcription factor
UniProt Gene Name:
Anti-SOX6 Antibody (CAB7115)Western blot analysis of extracts of various cell lines, using SOX6 antibody (CAB7115) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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