Developmental Biology
Anti-SOCS4 Antibody (CAB8003)
- SKU:
- CAB8003
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
| Antibody Name: | SOCS4 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8003 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SOCS4 (NP_543143.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MCF7, 293T, Mouse liver, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SOCS4 (NP_543143.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAEN NENI SKNV DVRP KTSR SRSA DRKD GYVW SGKK LSWS KKSE SYSD AETV NGIE KTEV SLRN QERK HSCS SIEL DLDH SCGH RFLG RSLK QKLQ DAVG QCFP IKNC SSRH SSGL PSKR KIHI SELM LDKC PFPP RSDL AFRW HFIK RHTA PINS KSDE WVST DLSQ TELR DGQL KRRN MEEN INCF SHTN VQPC VITT DNAL CREG PMTG SVMN LVSN NSIE DSDM DSDD EILT LCTS SRKR NKPK WDLD DEIL QLET PPKY HTQI DY |
| Gene ID: | 122809 |
| Uniprot: | Q8WXH5 |
| Cellular Location: | |
| Calculated MW: | 50kDa |
| Observed MW: | 51kDa |
| Synonyms: | SOCS4, SOCS7 |
| Background: | The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | SOCS4: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 14q22.1 Cellular Component: cytoplasm Molecular Function:protein binding; protein kinase inhibitor activity Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of JAK-STAT cascade |
| NCBI Summary: | The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WXH5 |
| NCBI GenInfo Identifier: | 20178106 |
| NCBI Gene ID: | 122809 |
| NCBI Accession: | Q8WXH5.1 |
| UniProt Related Accession: | Q8WXH5 |
| Molecular Weight: | 50,623 Da |
| NCBI Full Name: | Suppressor of cytokine signaling 4 |
| NCBI Synonym Full Names: | suppressor of cytokine signaling 4 |
| NCBI Official Symbol: | SOCS4 |
| NCBI Official Synonym Symbols: | SOCS7 |
| NCBI Protein Information: | suppressor of cytokine signaling 4 |
| UniProt Protein Name: | Suppressor of cytokine signaling 4 |
| UniProt Synonym Protein Names: | Suppressor of cytokine signaling 7; SOCS-7 |
| Protein Family: | Suppressor of cytokine signaling |
| UniProt Gene Name: | SOCS4 |
| UniProt Entry Name: | SOCS4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SOCS4 antibody (CAB8003) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using SOCS4 antibody (CAB8003) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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