Anti-SNX1 Antibody (CAB3398)
- SKU:
- CAB3398
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HsT17379
- Synonyms:
- VPS5
- Research Area:
- Cell Biology
Description
| Product Name: | SNX1 Rabbit mAb |
| Product Code: | CAB3398 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HsT17379, VPS5 |
| Applications: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SNX1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, 293T, HepG2, Rat testis |
| Immunogen: | A synthesized peptide derived from human SNX1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6642 |
| Uniprot: | Q13596 |
| Calculated MW: | 74kDa |
| Observed MW: | 74kDa |
| UniProt Protein Function: | SNX1: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 15q22.31 Cellular Component: cytoplasm; early endosome membrane; endosome membrane; extrinsic to membrane; intracellular membrane-bound organelle; membrane; protein complex; retromer complex Molecular Function:epidermal growth factor receptor binding; identical protein binding; insulin receptor binding; phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity Biological Process: intracellular protein transport; receptor internalization; retrograde transport, endosome to Golgi; vesicle organization and biogenesis |
| NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13596 |
| NCBI GenInfo Identifier: | 17380569 |
| NCBI Gene ID: | 6642 |
| NCBI Accession: | Q13596.3 |
| UniProt Secondary Accession: | Q13596,O60750, O60751, Q6ZRJ8, A6NM19, A8K6T7, H0Y2M5 |
| UniProt Related Accession: | Q13596 |
| Molecular Weight: | 63,082 Da |
| NCBI Full Name: | Sorting nexin-1 |
| NCBI Synonym Full Names: | sorting nexin 1 |
| NCBI Official Symbol: | SNX1 |
| NCBI Official Synonym Symbols: | VPS5; HsT17379 |
| NCBI Protein Information: | sorting nexin-1 |
| UniProt Protein Name: | Sorting nexin-1 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX1 |
| UniProt Entry Name: | SNX1_HUMAN |
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