| UniProt Protein Function: | SMURF1: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Interacts with TRAF4. Interacts (via HECT domain) with FBXL15 (via LRR repeats). Interacts with SMAD7 and TGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF-beta receptor degradation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; Ubiquitin conjugating system; EC 6.3.2.-; Ligase; Ubiquitin ligase Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: axon; cell soma; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; plasma membrane Molecular Function:activin binding; ligase activity; phospholipid binding; protein binding; ubiquitin-protein ligase activity Biological Process: BMP signaling pathway; cell differentiation; ectoderm development; negative regulation of BMP signaling pathway; negative regulation of ossification; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of defense response to virus by host; proteasomal ubiquitin-dependent protein catabolic process; protein export from nucleus; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; receptor catabolic process; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent SMAD protein catabolic process; Wnt receptor signaling pathway, planar cell polarity pathway |
| NCBI Summary: | This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010] |
| UniProt Code: | Q9HCE7 |
| NCBI GenInfo Identifier: | 31317290 |
| NCBI Gene ID: | 57154 |
| NCBI Accession: | NP_851994.1 |
| UniProt Secondary Accession: | Q9HCE7,O75853, Q547Q3, Q9UJT8, A4D279, B7ZMB6, B9EGV3 |
| UniProt Related Accession: | Q9HCE7 |
| Molecular Weight: | 83,440 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase SMURF1 isoform 2 |
| NCBI Synonym Full Names: | SMAD specific E3 ubiquitin protein ligase 1 |
| NCBI Official Symbol: | SMURF1 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase SMURF1; hSMURF1; E3 ubiquitin ligase SMURF1; Smad-specific E3 ubiquitin ligase 1; Smad ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase SMURF1 |
| UniProt Synonym Protein Names: | SMAD ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1 |
| UniProt Gene Name: | SMURF1 |
| UniProt Entry Name: | SMUF1_HUMAN |
