Antibody Name:	Anti-SMARCAD1 Antibody
Antibody SKU:	CAB5850
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SMARCAD1 (NP_001121901.1).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SMARCAD1 (NP_001121901.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MNLF NLDR FRFE KRNK IEEA PEAT PQPS QPGP SSPI SLSA EEEN AEGE VSRA NTPD SDIT EKTE DSSV PETP DNER KASI SYFK NQRG IQYI DLSS DSED VVSP NCSN TVQE KTFN KDTV IIVS EPSE DEES QGLP TMAR RNDD ISEL EDLS ELED LKDA KLQT LKEL FPQR SDND LLKL IEST STMD GAIA AALL MFGD AGGG PRKR KLSS SSEP YEED EFND DQSI KKTR LDHG EESN ESAE SSSN WEKQ ESIV LKLQ KEFP NFDK QELR EVLK EHEW MYTE ALES LKVF AEDQ DMQY
Gene ID:	56916
Uniprot:	Q9H4L7
Cellular Location:	Chromosome, Nucleus
Calculated MW:	68kDa/117kDa
Observed MW:	Refer to figures

Synonyms:

SMARCAD1, ADERM, BASNS, ETL1, HEL1

Background:

This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

UniProt Protein Function:	SMARCAD1: an ubiquitous enzyme with ATP-dependent DNA helicase activity. Belongs to the SNF2/RAD54 helicase family. Two alternatively spliced human isoforms have been described.
UniProt Protein Details:	Protein type:Helicase; Adaptor/scaffold; EC 3.6.4.12 Chromosomal Location of Human Ortholog: 4q22.3 Cellular Component: nucleoplasm; heterochromatin; nuclear matrix; nuclear replication fork Molecular Function:protein binding; nucleic acid binding; DNA binding; helicase activity; ATP binding Biological Process: chromatin remodeling; regulation of DNA recombination; positive regulation of transcription, DNA-dependent; DNA double-strand break processing; ATP-dependent chromatin remodeling; nucleotide metabolic process; chromatin modification; protein homooligomerization; chromosome separation Disease: Adermatoglyphia
NCBI Summary:	This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:	Q9H4L7
NCBI GenInfo Identifier:	306526240
NCBI Gene ID:	56916
NCBI Accession:	Q9H4L7.2
UniProt Secondary Accession:	Q9H4L7,Q05D56, Q96SX1, Q9H017, Q9H860, Q9NPU9, Q9ULU7 B7Z799,
UniProt Related Accession:	Q9H4L7
Molecular Weight:	1026
NCBI Full Name:	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
NCBI Synonym Full Names:	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
NCBI Official Symbol:	SMARCAD1
NCBI Official Synonym Symbols:	ETL1; HEL1; ADERM
NCBI Protein Information:	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1; ATP-dependent helicase 1
UniProt Protein Name:	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
UniProt Synonym Protein Names:	ATP-dependent helicase 1; hHEL1
Protein Family:	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily
UniProt Gene Name:	SMARCAD1
UniProt Entry Name:	SMRCD_HUMAN

	Immunohistochemistry of paraffin-embedded human lung cancer using SMARCAD1 antibody (CAB5850) at dilution of 1:100 (40x lens).
	Immunofluorescence analysis of A549 cells using SMARCAD1 antibody (CAB5850). Blue: DAPI for nuclear staining.