Signal Transduction Antibodies 3
Anti-SLCO1B1 Antibody (CAB17082)
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- SKU:
- CAB17082
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLCO1B1 Antibody |
| Antibody SKU: | CAB17082 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 597-691 of human SLCO1B1 (NP_006437.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 597-691 of human SLCO1B1 (NP_006437.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TTCI KWST NNCG TRGS CRTY NSTS FSRV YLGL SSML RVSS LVLY IILI YAMK KKYQ EKDI NASE NGSV MDEA NLES LNKN KHFV PSAG ADSE THC |
| Gene ID: | 10599 |
| Uniprot: | Q9Y6L6 |
| Cellular Location: | |
| Calculated MW: | 76kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 |
| Background: | This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. |
| UniProt Protein Function: | SLCO1B1: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. Defects in SLCO1B1 are a cause of hyperbilirubinemia, Rotor type (HBLRR). An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Belongs to the organo anion transporter (TC 2.A.60) family. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 12p Cellular Component: integral to plasma membrane; membrane; plasma membrane Molecular Function:bile acid transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; thyroid hormone transmembrane transporter activity Biological Process: bile acid and bile salt transport; bile acid metabolic process; organic anion transport; sodium-independent organic anion transport Disease: Hyperbilirubinemia, Rotor Type |
| NCBI Summary: | This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q9Y6L6 |
| NCBI GenInfo Identifier: | 12643959 |
| NCBI Gene ID: | 10599 |
| NCBI Accession: | Q9Y6L6.2 |
| UniProt Secondary Accession: | Q9Y6L6,Q29R64, Q9NQ37, Q9UBF3, Q9UH89, B2R7G2, |
| UniProt Related Accession: | Q9Y6L6 |
| Molecular Weight: | 76,449 Da |
| NCBI Full Name: | Solute carrier organic anion transporter family member 1B1 |
| NCBI Synonym Full Names: | solute carrier organic anion transporter family member 1B1 |
| NCBI Official Symbol: | SLCO1B1 |
| NCBI Official Synonym Symbols: | LST1; HBLRR; LST-1; OATP2; OATPC; OATP-C; OATP1B1; SLC21A6 |
| NCBI Protein Information: | solute carrier organic anion transporter family member 1B1 |
| UniProt Protein Name: | Solute carrier organic anion transporter family member 1B1 |
| UniProt Synonym Protein Names: | Liver-specific organic anion transporter 1; LST-1; OATP-C; Sodium-independent organic anion-transporting polypeptide 2; OATP-2; Solute carrier family 21 member 6 |
| Protein Family: | Solute carrier organic anion transporter family |
| UniProt Gene Name: | SLCO1B1 |
| UniProt Entry Name: | SO1B1_HUMAN |
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