Signal Transduction Antibodies 1

Anti-SLC6A18 Antibody (CAB12860)

(No reviews yet) Write a Review
SKU:
CAB12860
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SLC6A18 Antibody
Antibody SKU:CAB12860
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 310-400 of human SLC6A18 (NP_872438.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Mouse kidney, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 310-400 of human SLC6A18 (NP_872438.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VLGF KATN DYEH CLDR NILS LIND FDFP EQSI SRDD YPAV LMHL NATW PKRV AQLP LKAC LLED FLDK SASG PGLA FVVF TETD LHMP GAP
Gene ID:348932
Uniprot:Q96N87
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:70kDa
Observed MW:71kDa
Synonyms:SLC6A18, Xtrp2
Background:
UniProt Protein Function:SLC6A18: Functions as a sodium and chloride-dependent neutral amino acid transporter. Genetic variations in SLC6A18 might contribute to the disease phentotype in some individuals with iminoglycinuria or hyperglycinuria, that carry variants in SLC36A2, SLC6A19 or SLC6A20. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:amino acid transmembrane transporter activity; transporter activity

Biological Process: amino acid transport; transport

NCBI Summary:The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Apr 2010]
UniProt Code:Q96N87
NCBI GenInfo Identifier:313104185
NCBI Gene ID:348932
NCBI Accession:Q96N87.2
UniProt Related Accession:Q96N87
Molecular Weight:71kDa
NCBI Full Name:Sodium-dependent neutral amino acid transporter B(0)AT3
NCBI Synonym Full Names:solute carrier family 6 member 18
NCBI Official Symbol:SLC6A18  
NCBI Official Synonym Symbols:Xtrp2  
NCBI Protein Information:sodium-dependent neutral amino acid transporter B(0)AT3
UniProt Protein Name:Sodium-dependent neutral amino acid transporter B(0)AT3
UniProt Synonym Protein Names:Sodium- and chloride-dependent transporter XTRP2; Solute carrier family 6 member 18; System B(0) neutral amino acid transporter AT3
UniProt Gene Name:SLC6A18  
Anti-SLC6A18 Antibody (CAB12860)Western blot analysis of extracts of various cell lines, using SLC6A18 antibody (CAB12860) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
View AllClose

0 Reviews

View AllClose

Related Products