Cell Biology Antibodies 15
Anti-SLC5A7 Antibody (CAB8247)
- SKU:
- CAB8247
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Description
Antibody Name: | Anti-SLC5A7 Antibody |
Antibody SKU: | CAB8247 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 421-580 of human SLC5A7 (NP_068587.1). |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | C6, SH-SY5Y, U-251MG, SGC-7901, Mouse brain, Rat brain |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 421-580 of human SLC5A7 (NP_068587.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | LLCV LFVK GTNT YGAV AGYV SGLF LRIT GGEP YLYL QPLI FYPG YYPD DNGI YNQK FPFK TLAM VTSF LTNI CISY LAKY LFES GTLP PKLD VFDA VVAR HSEE NMDK TILV KNEN IKLD ELAL VKPR QSMT LSST FTNK EAFL DVDS SPEG SGTE DNLQ |
Gene ID: | 60482 |
Uniprot: | Q9GZV3 |
Cellular Location: | Membrane, Multi-pass membrane protein |
Calculated MW: | 63kDa |
Observed MW: | 66-75KDa |
Synonyms: | SLC5A7, CHT, CHT1, CMS20, HMN7A |
Background: | This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | SLC5A7: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 2q12 Cellular Component: cell soma; integral to membrane; plasma membrane Molecular Function:choline binding; choline transmembrane transporter activity; choline:sodium symporter activity Biological Process: synaptic transmission; acetylcholine biosynthetic process; neurotransmitter secretion; sodium ion transport; neuromuscular synaptic transmission; choline transport; transmembrane transport; synaptic transmission, cholinergic Disease: Neuronopathy, Distal Hereditary Motor, Type Viia |
NCBI Summary: | Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons (Apparsundaram et al., 2000 [PubMed 11027560]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9GZV3 |
NCBI GenInfo Identifier: | 56404957 |
NCBI Gene ID: | 10992 |
NCBI Accession: | Q9GZV3.1 |
UniProt Secondary Accession: | Q9GZV3,Q53TF2, |
UniProt Related Accession: | Q9GZV3 |
Molecular Weight: | 895 |
NCBI Full Name: | High affinity choline transporter 1 |
NCBI Synonym Full Names: | solute carrier family 5 (sodium/choline cotransporter), member 7 |
NCBI Official Symbol: | SLC5A7 |
NCBI Official Synonym Symbols: | CHT; CHT1; hCHT; HMN7A |
NCBI Protein Information: | high affinity choline transporter 1; solute carrier family 5 member 7; hemicholinium-3-sensitive choline transporter; solute carrier family 5 (choline transporter), member 7; high affinity choline transporter; hemicholinium-3-sensitive choline transporter |
UniProt Protein Name: | High affinity choline transporter 1 |
UniProt Synonym Protein Names: | Hemicholinium-3-sensitive choline transporter; CHT; Solute carrier family 5 member 7 |
Protein Family: | Splicing factor |
UniProt Gene Name: | SLC5A7 |
UniProt Entry Name: | SC5A7_HUMAN |
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