Signal Transduction Antibodies 2

Anti-SLC17A5 Antibody (CAB15426)

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SKU:
CAB15426
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC17A5 Antibody
Antibody SKU:CAB15426
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC17A5 (NP_036566.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse eye, Mouse skin, Mouse kidney, Rat kidney
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC17A5 (NP_036566.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRSP VRDL ARND GEES TDRT PLLP GAPR AEAA PVCC SARY NLAI LAFF GFFI VYAL RVNL SVAL VDMV DSNT TLED NRTS KACP EHSA PIKV HHNQ TGKK
Gene ID:26503
Uniprot:Q9NRA2
Cellular Location:Cell membrane, Cytoplasmic vesicle, Lysosome membrane, Multi-pass membrane protein, secretory vesicle, synaptic vesicle membrane
Calculated MW:30kDa/54kDa
Observed MW:35kDa
Synonyms:SLC17A5, AST, ISSD, NSD, SD, SIALIN, SIASD, SLD, sialin
Background:This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form.
UniProt Protein Function:Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO3-/H+ cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
NCBI Summary:This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NRA2
NCBI GenInfo Identifier:6912666
NCBI Gene ID:26503
NCBI Accession:NP_036566.1
UniProt Secondary Accession:Q9NRA2,Q5SZ76, Q8NBR5, Q9UGH0,
UniProt Related Accession:Q9NRA2
Molecular Weight:30,667 Da
NCBI Full Name:sialin
NCBI Synonym Full Names:solute carrier family 17 member 5
NCBI Official Symbol:SLC17A5  
NCBI Official Synonym Symbols:SD; AST; NSD; SLD; ISSD; SIASD; SIALIN  
NCBI Protein Information:sialin
UniProt Protein Name:Sialin
UniProt Synonym Protein Names:H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular H(+)/Aspartate-glutamate cotransporter
Protein Family:Allatostatin
UniProt Gene Name:SLC17A5  
Anti-SLC17A5 Antibody (CAB15426)Western blot analysis of extracts of various cell lines, using SLC17A5 antibody (CAB15426) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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