Epigenetics & Nuclear Signaling Antibodies 3

Anti-SKIV2L2 Antibody (CAB5576)

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SKU:
CAB5576
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SKIV2L2 Antibody
Antibody SKU:CAB5576
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IP
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-304 of human SKIV2L2 (NP_056175.3).
Application:WB IHC IP
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, 22RV1, 293T, U-87MG, Mouse testis, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-304 of human SKIV2L2 (NP_056175.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MADA FGDE LFSV FEGD STTA AGTK KDKE KDKG KWKG PPGS ADKA GKRF DGKL QSES TNNG KNKR DVDF EGTD EPIF GKKP RIEE SITE DLSL ADLM PRVK VQSV ETVE GCTH EVAL PAEE DYLP LKPR VGKA AKEY PFIL DAFQ REAI QCVD NNQS VLVS AHTS AGKT VCAE YAIA LALR EKQR VIFT SPIK ALSN QKYR EMYE EFQD VGLM TGDV TINP TASC LVMT TEIL RSML YRGS EVMR EVAW VIFD EIHY MRDS ERGV VWEE TIIL LPDN VHYV FLSA TIPN ARQF AEWI CHLH KQPC
Gene ID:23517
Uniprot:P42285
Cellular Location:Nucleus, nucleolus, nucleoplasm
Calculated MW:117kDa
Observed MW:123kDa
Synonyms:SKIV2L2, Dob1, KIAA0052, Mtr4, fSAP118
Background:
UniProt Protein Function:SKIV2L2: May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Belongs to the helicase family. SKI2 subfamily.
UniProt Protein Details:

Protein type:Spliceosome; EC 3.6.4.13; Nucleolus; DNA-binding; Helicase

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: nucleoplasm; nucleolus; exosome (RNase complex); nucleus

Molecular Function:protein binding; helicase activity; ATP binding

Biological Process: nuclear mRNA splicing, via spliceosome; maturation of 5.8S rRNA

UniProt Code:P42285
NCBI GenInfo Identifier:71153172
NCBI Gene ID:23517
NCBI Accession:P42285.3
UniProt Secondary Accession:P42285,Q2M386, Q6MZZ8, Q6P170, Q8N5R0, Q8TAG2,
UniProt Related Accession:P42285
Molecular Weight:1042
NCBI Full Name:Superkiller viralicidic activity 2-like 2
NCBI Synonym Full Names:superkiller viralicidic activity 2-like 2 (S. cerevisiae)
NCBI Official Symbol:SKIV2L2  
NCBI Official Synonym Symbols:Dob1; Mtr4; fSAP118; KIAA0052  
NCBI Protein Information:superkiller viralicidic activity 2-like 2; TRAMP-like complex helicase; ATP-dependent helicase SKIV2L2; ATP-dependent RNA helicase SKIV2L2; functional spliceosome-associated protein 118
UniProt Protein Name:Superkiller viralicidic activity 2-like 2
UniProt Synonym Protein Names:ATP-dependent RNA helicase SKIV2L2; TRAMP-like complex helicase
Protein Family:ATP-dependent RNA helicase
UniProt Gene Name:SKIV2L2  
UniProt Entry Name:SK2L2_HUMAN
Anti-SKIV2L2 Antibody (CAB5576)Western blot analysis of extracts of various cell lines, using SKIV2L2 antibody (CAB5576) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-SKIV2L2 Antibody (CAB5576)Immunohistochemistry of paraffin-embedded human breast cancer using SKIV2L2 antibody (CAB5576) at dilution of 1:100 (40x lens).
Anti-SKIV2L2 Antibody (CAB5576)Immunohistochemistry of paraffin-embedded mouse testis using SKIV2L2 antibody (CAB5576) at dilution of 1:100 (40x lens).
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