Cell Biology Antibodies 13
Anti-SIGLEC1 Antibody (CAB17533)
(No reviews yet)
Write a Review
- SKU:
- CAB17533
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SIGLEC1 Antibody |
| Antibody SKU: | CAB17533 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-300 of human SIGLEC1 (NP_075556.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-300 of human SIGLEC1 (NP_075556.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EVPD GITA IWYY DYSG QRQV VSHS ADPK LVEA RFRG RTEF MGNP EHRV CNLL LKDL QPED SGSY NFRF EISE VNRW SDVK GTLV TVTE EPRV PTIA SPVE LLEG TEVD FNCS TPYV CLQE QVRL QWQG QDPA RSVT FNSQ KFEP TGVG HLET LHMA MSWQ DHGR ILRC QLSV ANHR AQSE IHLQ VKYA PKGV KILL SPSG RNIL PGEL VTLT CQVN SSYP AVSS IKWL KDGV RLQT KTGV LHLP QAAW SDA |
| Gene ID: | 6614 |
| Uniprot: | Q9BZZ2 |
| Cellular Location: | |
| Calculated MW: | 200kDa |
| Observed MW: | 200kDa |
 | Western blot - SIGLEC1 Polyclonal Antibody (CAB17533) |
| Synonyms: | SN, CD169, SIGLEC-1, SIGLEC1 |
| Background: | This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. |
| UniProt Protein Function: | SIGLEC1: Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 20p13 Cellular Component: integral to membrane; plasma membrane; extracellular region Molecular Function:carbohydrate binding Biological Process: cell-cell adhesion; cell-matrix adhesion; endocytosis; inflammatory response |
| NCBI Summary: | This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BZZ2 |
| NCBI GenInfo Identifier: | 18202745 |
| NCBI Gene ID: | 6614 |
| NCBI Accession: | Q9BZZ2.2 |
| UniProt Secondary Accession: | Q9BZZ2,Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7, |
| UniProt Related Accession: | Q9BZZ2 |
| Molecular Weight: | 181,733 Da |
| NCBI Full Name: | Sialoadhesin |
| NCBI Synonym Full Names: | sialic acid binding Ig-like lectin 1, sialoadhesin |
| NCBI Official Symbol: | SIGLEC1 |
| NCBI Official Synonym Symbols: | SN; CD169; SIGLEC-1; dJ1009E24.1 |
| NCBI Protein Information: | sialoadhesin; sialic acid-binding Ig-like lectin 1; sialic acid-binding immunoglobulin-like lectin 1 |
| UniProt Protein Name: | Sialoadhesin |
| UniProt Synonym Protein Names: | Sialic acid-binding Ig-like lectin 1; Siglec-1; CD_antigen: CD169 |
| Protein Family: | Sialoadhesin |
| UniProt Gene Name: | SIGLEC1 |
| UniProt Entry Name: | SN_HUMAN |
Related Products
Siglec1 Polyclonal Antibody (CAB22677)
Siglec1 Polyclonal Antibody (CAB22677)The product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!
Anti-SIGLEC10 Antibody (CAB20413)
OverviewProduct Name:SIGLEC10 Rabbit pAbProduct Code:CAB20413Size:50uL, 100uLSynonyms:SLG2, PRO940, SIGLEC-10Applicati
