Epigenetics & Nuclear Signaling Antibodies 5

Anti-SETD7 Antibody (CAB9225)

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SKU:
CAB9225
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SETD7 Antibody
Antibody SKU:CAB9225
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human SETD7
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:C6, Mouse brain, Mouse spleen, Rat lung
Immunogen:A synthesized peptide derived from human SETD7
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:80854
Uniprot:Q8WTS6
Cellular Location:
Calculated MW:41kDa
Observed MW:48KDa
Synonyms:KMT7, SET7, SET7/9, SET9
Background:
UniProt Protein Function:Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
UniProt Code:Q8WTS6
NCBI GenInfo Identifier:25091217
NCBI Gene ID:80854
NCBI Accession:Q8WTS6.1
UniProt Secondary Accession:Q8WTS6,Q0VAH3, Q4W5A9, Q9C0E6, B5WWL3,
UniProt Related Accession:Q8WTS6
Molecular Weight:40,721 Da
NCBI Full Name:Histone-lysine N-methyltransferase SETD7
NCBI Synonym Full Names:SET domain containing lysine methyltransferase 7
NCBI Official Symbol:SETD7  
NCBI Official Synonym Symbols:KMT7; SET7; SET9; SET7/9  
NCBI Protein Information:histone-lysine N-methyltransferase SETD7
UniProt Protein Name:Histone-lysine N-methyltransferase SETD7
UniProt Synonym Protein Names:Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9
Protein Family:Histone-lysine N-methyltransferase
UniProt Gene Name:SETD7  
UniProt Entry Name:SETD7_HUMAN
Anti-SETD7 Antibody (CAB9225)Western blot - SETD7 Rabbit mAb (CAB9225)
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