Anti-SETD1B Antibody (CAB20155)
- SKU:
- CAB20155
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- KMT2G
- Synonyms:
- Set1B
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | SETD1B Rabbit pAb |
| Product Code: | CAB20155 |
| Size: | 50uL, 100uL |
| Synonyms: | KMT2G, Set1B |
| Applications: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SETD1B. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:1000 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse lung, Rat lung |
| Immunogen: | Recombinant protein of human SETD1B. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23067 |
| Uniprot: | Q9UPS6 |
| Calculated MW: | 213kDa |
| Observed MW: | 250KDa |
| UniProt Protein Function: | SETD1B: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro. |
| UniProt Protein Details: | Protein type:Methyltransferase, protein lysine; Methyltransferase; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43 Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: nucleoplasm; histone methyltransferase complex; cytoplasm; nuclear speck; chromosome Molecular Function:protein binding; histone lysine N-methyltransferase activity (H3-K4 specific); RNA binding; nucleotide binding Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; histone H3-K4 methylation |
| NCBI Summary: | SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9UPS6 |
| NCBI GenInfo Identifier: | 597439633 |
| NCBI Gene ID: | 23067 |
| NCBI Accession: | Q9UPS6.3 |
| UniProt Secondary Accession: | Q9UPS6,F6MFW1, |
| UniProt Related Accession: | Q9UPS6 |
| Molecular Weight: | Calculated MW: 208kDa/212kDaObserved MW: 263kDa |
| NCBI Full Name: | Histone-lysine N-methyltransferase SETD1B |
| NCBI Synonym Full Names: | SET domain containing 1B |
| NCBI Official Symbol: | SETD1B |
| NCBI Official Synonym Symbols: | KMT2G; Set1B |
| NCBI Protein Information: | histone-lysine N-methyltransferase SETD1B; hSET1B; lysine N-methyltransferase 2G; SET domain-containing protein 1B |
| UniProt Protein Name: | Histone-lysine N-methyltransferase SETD1B |
| UniProt Synonym Protein Names: | Lysine N-methyltransferase 2G; SET domain-containing protein 1B; hSET1B |
| Protein Family: | Histone-lysine N-methyltransferase |
| UniProt Gene Name: | SETD1B |
| UniProt Entry Name: | SET1B_HUMAN |
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