Anti-sestrin 1 Antibody (CAB19787)
- SKU:
- CAB19787
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PA26
- Synonyms:
- SEST1
Description
| Product Name: | sestrin 1 Rabbit mAb |
| Product Code: | CAB19787 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PA26, SEST1 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human sestrin 1 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, PC-3 |
| Immunogen: | A synthesized peptide derived from human sestrin 1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 27244 |
| Uniprot: | Q9Y6P5 |
| Calculated MW: | 70kDa |
| Observed MW: | 66KDa |
| UniProt Protein Function: | SESN1: Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth. Belongs to the sestrin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q21 Cellular Component: nucleus Biological Process: negative regulation of cell proliferation; regulation of protein kinase B signaling cascade; cell cycle arrest; response to DNA damage stimulus |
| NCBI Summary: | This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q9Y6P5 |
| NCBI GenInfo Identifier: | 13633953 |
| NCBI Gene ID: | 27244 |
| NCBI Accession: | Q9Y6P5.2 |
| UniProt Secondary Accession: | Q9Y6P5,Q2M2B7, Q5T316, Q9NV00, Q9UPD5, Q9Y6P6, |
| UniProt Related Accession: | Q9Y6P5 |
| Molecular Weight: | 49,624 Da |
| NCBI Full Name: | Sestrin-1 |
| NCBI Synonym Full Names: | sestrin 1 |
| NCBI Official Symbol: | SESN1 |
| NCBI Official Synonym Symbols: | PA26; SEST1 |
| NCBI Protein Information: | sestrin-1; p53 activated gene 26; p53 regulated PA26 nuclear protein |
| UniProt Protein Name: | Sestrin-1 |
| UniProt Synonym Protein Names: | p53-regulated protein PA26 |
| Protein Family: | Sestrin |
| UniProt Gene Name: | SESN1 |
| UniProt Entry Name: | SESN1_HUMAN |
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