KO Validated Antibodies 2

Anti-SERPINB5 Antibody (CAB19848)[KO Validated]

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SKU:
CAB19848
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SERPINB5 Antibody [KO Validated]
Antibody SKU:CAB19848
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human SERPINB5.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa
Immunogen:Recombinant protein of human SERPINB5.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5268
Uniprot:P36952
Cellular Location:Secreted, extracellular space
Calculated MW:25kDa/42kDa
Observed MW:42KDa
Anti-SERPINB5 Antibody [KO Validated] (CAB19848)Western blot analysis of extracts from normal (control) and SERPINB5 knockout (KO) HeLa cells, using SERPINB5 antibody (CAB19848) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Synonyms:SERPINB5, PI5, maspin, serpin B5
Background:
UniProt Protein Function:maspin: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 18q21.33

Cellular Component: extracellular space; cytoplasm

Molecular Function:serine-type endopeptidase inhibitor activity; protein binding

Biological Process: extracellular matrix organization and biogenesis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation

UniProt Code:P36952
NCBI GenInfo Identifier:229462757
NCBI Gene ID:5268
NCBI Accession:P36952.2
UniProt Secondary Accession:P36952,Q6N0B4, Q8WW89, B2R6Y4,
UniProt Related Accession:P36952
Molecular Weight:25,763 Da
NCBI Full Name:Serpin B5
NCBI Synonym Full Names:serpin peptidase inhibitor, clade B (ovalbumin), member 5
NCBI Official Symbol:SERPINB5  
NCBI Official Synonym Symbols:PI5; maspin  
NCBI Protein Information:serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
UniProt Protein Name:Serpin B5
UniProt Synonym Protein Names:Maspin; Peptidase inhibitor 5; PI-5
Protein Family:Serpin
UniProt Gene Name:SERPINB5  
UniProt Entry Name:SPB5_HUMAN
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