Immunology Antibodies 3

Alpha-1 Antitrypsin (SERPINA1) Rabbit Monoclonal Antibody (CAB4966)

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SKU:
CAB4966
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse, Rat
Synonyms:
PI, A1A, AAT, PI1, A1AT, nNIF, PRO2275, alpha1AT, Alpha-1 Antitrypsin (SERPINA1)
Research Use:
Immunology
Frequently bought together:

Description

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Alpha-1 Antitrypsin (SERPINA1) Monoclonal Antibody (CAB4966)

The Alpha-1 Antitrypsin (SERPINA1) Monoclonal Antibody (CAB4966) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in various applications such as Western blotting and immunohistochemistry.SERPINA1, also known as alpha-1-antitrypsin, is a crucial inhibitor of proteases that can cause tissue damage. Dysregulation of SERPINA1 has been implicated in a variety of diseases, including emphysema, liver cirrhosis, and even certain cancers.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.

Product Name:Alpha-1 Antitrypsin (SERPINA1) Monoclonal Antibody
SKU:CAB4966
Size:20μL, 100μL
Reactivity:Mouse, Rat
Clone Number:ARC1212
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MPSS VSWG ILLL AGLC CLVP VSLA EDPQ GDAA QKTD TSHH DQDH PTFN KITP NLAE FAFS LYRQ LAHQ SNST NIFF SPVS IATA FAML SLGT KADT HDEI LEGL NFNL TEIP EAQI HEGF QELL RTLN QPDS QLQL TTGN GLFL SEGL KLVD KFLE DVKK LYHS EAFT VNFG DTEE AKKQ INDY VEKG TQGK IVDL VKEL DRDT VFAL VNYI FFKG KWER PFEV KDTE EEDF HVDQ VTTV KVPM MKRL GMFN IQHC KKLS SWVL LMKY LGNA TAIF FLPD EGKL QHLE NELT HDII TKFL ENED RRSA SLHL PKLS ITGT YDLK SVLG QLGI TKVF SNGA DLSG VTEE APLK LSKA VHKA VLTI DEKG TEAA GAMF LEAI PMSI PPEV KFNK PFVF LMIE QNTK SPLF MGKV VNPT QK
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:5000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PI, A1A, AAT, PI1, A1AT, nNIF, PRO2275, alpha1AT, Alpha-1 Antitrypsin (SERPINA1)
Positive Sample:Mouse lung, Mouse liver, Rat lung
Cellular Localization:Endoplasmic Reticulum, Secreted, Extracellular Matrix, Extracellular Space.
Calculated MW:47kDa
Observed MW:45kDa

The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene.

Purification MethodAffinity purification
Gene ID5265
RRIDAB_2863400
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using Alpha-1 Antitrypsin (Alpha-1 Antitrypsin (SERPINA1)) Rabbit mAb (CAB4966) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
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