Developmental Biology

Anti-SEMA6D Antibody (CAB14935)

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SKU:
CAB14935
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-SEMA6D Antibody
Antibody SKU:CAB14935
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human SEMA6D (NP_705871.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human SEMA6D (NP_705871.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AVSF PEDD EPLN TVDY HYSR QYPV FRGR PSGN ESQH RLDF QLML KIRD TLYI AGRD QVYT VNLN EMPK TEVI PNKK LTWR SRQQ DREN CAM
Gene ID:80031
Uniprot:Q8NFY4
Cellular Location:Cell membrane, Cytoplasm, Single-pass type I membrane protein
Calculated MW:54kDa/67kDa/111-119kDa
Observed MW:Refer to figures
Synonyms:SEMA6D
Background:Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.
UniProt Protein Function:SEMA6D: a single-pass type I membrane protein of the semaphorin family that shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Seven alternatively spliced human isoforms have been reported. All are intrinsic membrane proteins except isoform 7, which is cytoplasmic.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:chemorepellent activity; semaphorin receptor binding

Biological Process: negative regulation of axon extension involved in axon guidance; neural crest cell migration; positive regulation of cell migration

NCBI Summary:Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
UniProt Code:Q8NFY4
NCBI GenInfo Identifier:74715611
NCBI Gene ID:80031
NCBI Accession:Q8NFY4.1
UniProt Secondary Accession:Q8NFY4,Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249, A6NF10 A6NM95, A6NNK1, A7E2A0,
UniProt Related Accession:Q8NFY4
Molecular Weight:67,538 Da
NCBI Full Name:Semaphorin-6D
NCBI Synonym Full Names:semaphorin 6D
NCBI Official Symbol:SEMA6D  
NCBI Protein Information:semaphorin-6D
UniProt Protein Name:Semaphorin-6D
Protein Family:Semaphorin
UniProt Gene Name:SEMA6D  
UniProt Entry Name:SEM6D_HUMAN
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