Developmental Biology
Anti-SEMA5B Antibody (CAB13819)
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- SKU:
- CAB13819
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-SEMA5B Antibody |
| Antibody SKU: | CAB13819 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 800-980 of human SEMA5B (NP_001243276.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 800-980 of human SEMA5B (NP_001243276.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RRAC ENGN SCLG CGVE FKTC NPEG CPEV RRNT PWTP WLPV NVTQ GGAR QEQR FRFT CRAP LADP HGLQ FGRR RTET RTCP ADGS GSCD TDAL VEVL LRSG STSP HTVS GGWA AWGP WSSC SRDC ELGF RVRK RTCT NPEP RNGG LPCV GDAA EYQD CNPQ ACPV RGAW SCWT SWSP CSAS C |
| Gene ID: | 54437 |
| Uniprot: | Q9P283 |
| Cellular Location: | Membrane, Single-pass type III membrane protein |
| Calculated MW: | 119kDa/123kDa/125kDa/131kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SEMA5B, SEMAG, SemG |
| Background: | This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SEMA5B: a single-pass type I membrane protein of the semaphorin family that may act as positive axonal guidance cues. Two alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3q21.1 Cellular Component: integral to membrane Molecular Function:receptor activity Biological Process: nervous system development; cell differentiation |
| NCBI Summary: | This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q9P283 |
| NCBI GenInfo Identifier: | 373432662 |
| NCBI Gene ID: | 54437 |
| NCBI Accession: | NP_001243277.1 |
| UniProt Secondary Accession: | Q9P283,Q6DD89, Q6UY12, Q9NW17, A8K5U2, B7Z393, F8W9U8 |
| UniProt Related Accession: | Q9P283 |
| Molecular Weight: | 125,913 Da |
| NCBI Full Name: | semaphorin-5B isoform 3 |
| NCBI Synonym Full Names: | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B |
| NCBI Official Symbol: | SEMA5B |
| NCBI Official Synonym Symbols: | SemG; SEMAG |
| NCBI Protein Information: | semaphorin-5B |
| UniProt Protein Name: | Semaphorin-5B |
| Protein Family: | Semaphorin |
| UniProt Gene Name: | SEMA5B |
| UniProt Entry Name: | SEM5B_HUMAN |
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