Developmental Biology

Anti-SEMA5B Antibody (CAB13819)

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SKU:
CAB13819
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-SEMA5B Antibody
Antibody SKU:CAB13819
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 800-980 of human SEMA5B (NP_001243276.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 800-980 of human SEMA5B (NP_001243276.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RRAC ENGN SCLG CGVE FKTC NPEG CPEV RRNT PWTP WLPV NVTQ GGAR QEQR FRFT CRAP LADP HGLQ FGRR RTET RTCP ADGS GSCD TDAL VEVL LRSG STSP HTVS GGWA AWGP WSSC SRDC ELGF RVRK RTCT NPEP RNGG LPCV GDAA EYQD CNPQ ACPV RGAW SCWT SWSP CSAS C
Gene ID:54437
Uniprot:Q9P283
Cellular Location:Membrane, Single-pass type III membrane protein
Calculated MW:119kDa/123kDa/125kDa/131kDa
Observed MW:Refer to figures
Synonyms:SEMA5B, SEMAG, SemG
Background:This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:SEMA5B: a single-pass type I membrane protein of the semaphorin family that may act as positive axonal guidance cues. Two alternatively spliced human isoforms have been described.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21.1

Cellular Component: integral to membrane

Molecular Function:receptor activity

Biological Process: nervous system development; cell differentiation

NCBI Summary:This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:Q9P283
NCBI GenInfo Identifier:373432662
NCBI Gene ID:54437
NCBI Accession:NP_001243277.1
UniProt Secondary Accession:Q9P283,Q6DD89, Q6UY12, Q9NW17, A8K5U2, B7Z393, F8W9U8
UniProt Related Accession:Q9P283
Molecular Weight:125,913 Da
NCBI Full Name:semaphorin-5B isoform 3
NCBI Synonym Full Names:sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
NCBI Official Symbol:SEMA5B  
NCBI Official Synonym Symbols:SemG; SEMAG  
NCBI Protein Information:semaphorin-5B
UniProt Protein Name:Semaphorin-5B
Protein Family:Semaphorin
UniProt Gene Name:SEMA5B  
UniProt Entry Name:SEM5B_HUMAN
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