Name: Anti-SEMA4A Antibody (CAB17205)
Brand: Cell Biology Antibodies 13
SKU: CAB17205
Availability: OutOfStock

Antibody Name:	Anti-SEMA4A Antibody
Antibody SKU:	CAB17205
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 320-580 of human SEMA4A (NP_071762.2).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HT-29

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 320-580 of human SEMA4A (NP_071762.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	IYAV FTSQ WQVG GTRS SAVC AFSL LDIE RVFK GKYK ELNK ETSR WTTY RGPE TNPR PGSC SVGP SSDK ALTF MKDH FLMD EQVV GTPL LVKS GVEY TRLA VETA QGLD GHSH LVMY LGTT TGSL HKAV VSGD SSAH LVEE IQLF PDPE PVRN LQLA PTQG AVFV GFSG GVWR VPRA NCSV YESC VDCV LARD PHCA WDPE SRTC CLLS APNL NSWK QDME RGNP EWAC ASGP MSRS LRPQ SRPQ IIKE VLAV PNSI LELP C
Gene ID:	64218
Uniprot:	Q9H3S1
Cellular Location:
Calculated MW:	69kDa/83kDa
Observed MW:	83kDa

Western blot - SEMA4A Rabbit pAb (CAB17205)

Synonyms:

SEMA4A, CORD10, RP35, SEMAB, SEMB

Background:

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

UniProt Protein Function:	SEMA4A: a single-pass type I membrane protein that inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Defects in SEMA4A are the cause of retinitis pigmentosa type 35 and cone-rod dystrophy type 10.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q22 Cellular Component: extracellular space; plasma membrane Molecular Function:chemorepellent activity; protein binding; semaphorin receptor binding Biological Process: negative chemotaxis; negative regulation of axon extension involved in axon guidance; neural crest cell migration; positive regulation of cell migration Disease: Cone-rod Dystrophy 10; Retinitis Pigmentosa 35
NCBI Summary:	This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
UniProt Code:	Q9H3S1
NCBI GenInfo Identifier:	29840871
NCBI Gene ID:	64218
NCBI Accession:	Q9H3S1.2
UniProt Secondary Accession:	Q9H3S1,Q5TCI5, Q5TCJ6, Q8WUA9, B2RDH8, B3KR76,
UniProt Related Accession:	Q9H3S1
Molecular Weight:	69,104 Da
NCBI Full Name:	Semaphorin-4A
NCBI Synonym Full Names:	semaphorin 4A
NCBI Official Symbol:	SEMA4A
NCBI Official Synonym Symbols:	RP35; SEMB; SEMAB; CORD10
NCBI Protein Information:	semaphorin-4A
UniProt Protein Name:	Semaphorin-4A
UniProt Synonym Protein Names:	Semaphorin-B; Sema B
Protein Family:	Semaphorin
UniProt Gene Name:	SEMA4A
UniProt Entry Name:	SEM4A_HUMAN