Cell Biology Antibodies 6
Anti-SELL Antibody (CAB1622)
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- SKU:
- CAB1622
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SELL Antibody |
| Antibody SKU: | CAB1622 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SELL (NP_000646.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, Raji, Mouse spleen, Mouse thymus, Rat thymus |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SELL (NP_000646.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGCR RTRE GPSK AMIF PWKC QSTQ RDLW NIFK LWGW TMLC CDFL AHHG TDCW TYHY SEKP MNWQ RARR FCRD NYTD LVAI QNKA EIEY LEKT LPFS RSYY |
| Gene ID: | 6402 |
| Uniprot: | P14151 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 42kDa/43kDa |
| Observed MW: | 74kDa |
| Synonyms: | SELL, CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1 |
| Background: | This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23-q25 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:heparin binding; protein binding; protease binding; cell adhesion molecule binding; glycosphingolipid binding; carbohydrate binding Biological Process: regulation of immune response; blood coagulation; cell adhesion; leukocyte migration; response to ATP Disease: Iga Nephropathy, Susceptibility To, 1 |
| NCBI Summary: | This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P14151 |
| NCBI GenInfo Identifier: | 126178 |
| NCBI Gene ID: | 6402 |
| NCBI Accession: | P14151.2 |
| UniProt Secondary Accession: | P14151,P15023, Q9UJ43, B2R6Q8, |
| UniProt Related Accession: | P14151 |
| Molecular Weight: | 43,618 Da |
| NCBI Full Name: | L-selectin |
| NCBI Synonym Full Names: | selectin L |
| NCBI Official Symbol: | SELL |
| NCBI Official Synonym Symbols: | TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1 |
| NCBI Protein Information: | L-selectin; gp90-MEL; pln homing receptor; lymph node homing receptor; lymphocyte adhesion molecule 1; leukocyte surface antigen Leu-8; CD62 antigen-like family member L; leukocyte-endothelial cell adhesion molecule 1 |
| UniProt Protein Name: | L-selectin |
| UniProt Synonym Protein Names: | CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD_antigen: CD62L |
| Protein Family: | L-selectin |
| UniProt Gene Name: | SELL |
| UniProt Entry Name: | LYAM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SELL antibody (CAB1622) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat testis using SELL antibody (CAB1622) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human tonsil using SELL antibody (CAB1622) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using SELL antibody (CAB1622) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of NIH/3T3 cells using SELL antibody (CAB1622) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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