Anti-Sec23A Antibody (CAB8613)

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SKU:
CAB8613
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CLSD
Research Area:
Cell Biology

Description

Product Name:Sec23A Rabbit mAb
Product Code:CAB8613
Size:20uL, 50uL, 100uL
Synonyms:CLSD
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Sec23AA
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2
Immunogen:A synthesized peptide derived from human Sec23AA
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10484
Uniprot:Q15436
Cellular Location:Golgi apparatus membrane, Peripheral membrane protein, Smooth endoplasmic reticulum membrane
Calculated MW:86kDa
Observed MW:85kDa
UniProt Protein Function:SEC23A: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with SEC23IP. Interacts with HTR4. Interacts with SLC6A4. Interacts with SEC16A. Belongs to the SEC23/SEC24 family. SEC23 subfamily.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q21.1

Cellular Component: COPII vesicle coat; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; perinuclear region of cytoplasm; smooth endoplasmic reticulum membrane

Molecular Function:protein binding; zinc ion binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; vesicle-mediated transport

Disease: Craniolenticulosutural Dysplasia

NCBI Summary:The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]
UniProt Code:Q15436
NCBI GenInfo Identifier:143811354
NCBI Gene ID:10484
NCBI Accession:Q15436.2
UniProt Secondary Accession:Q15436,Q8NE16, B2R5P4, B3KXI2,
UniProt Related Accession:Q15436
Molecular Weight:63,101 Da
NCBI Full Name:Protein transport protein Sec23A
NCBI Synonym Full Names:Sec23 homolog A, coat complex II component
NCBI Official Symbol:SEC23A  
NCBI Official Synonym Symbols:CLSD  
NCBI Protein Information:protein transport protein Sec23A
UniProt Protein Name:Protein transport protein Sec23A
UniProt Synonym Protein Names:SEC23-related protein A
Protein Family:SEC23-interacting protein
UniProt Gene Name:SEC23A  
UniProt Entry Name:SC23A_HUMAN
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